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pubmed-article:20584554pubmed:abstractTextThe association between anti-triosephosphate isomerase (TPI) antibodies and MRL/MpJ-Fas(lpr) (MRL/lpr) mice was examined. We found that serum anti-TPI antibody levels in MRL/lpr mice, measured by enzyme-linked immunosorbent assay, were significantly higher than that of age-matched Balb/c mice and NZB/WF1 mice. Anti-TPI antibodies were detected in serum and cerebrospinal fluid in MRL/lpr mice by Western blotting. Inoculation of anti-TPI monoclonal antibody-producing hybridoma into the brain of Balb/c mice resulted in immunoglobulin deposition in the regions near the ventricles, hippocampus, and choroid plexus. Anti-TPI antibodies may play a role in the etiology of brain damage and behavioral deficits in MRL/lpr mice.lld:pubmed
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pubmed-article:20584554pubmed:authorpubmed-author:OhiraHiromasa...lld:pubmed
pubmed-article:20584554pubmed:authorpubmed-author:ShioKioriKlld:pubmed
pubmed-article:20584554pubmed:copyrightInfoCopyright © 2010 Elsevier B.V. All rights reserved.lld:pubmed
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pubmed-article:20584554pubmed:articleTitleAssociation of anti-triosephosphate isomerase antibody and MRL/MpJ-Faslpr mouse.lld:pubmed
pubmed-article:20584554pubmed:affiliationFukushima Medical University, Department of Gastroenterology and Rheumatology, School of Medicine, 1 Hikarigaoka, Fukushima 960-1295, Japan.lld:pubmed
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