| pubmed-article:20581821 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C1416806 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C0005775 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C0302583 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C0054858 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C2825311 | lld:lifeskim |
| pubmed-article:20581821 | lifeskim:mentions | umls-concept:C2349209 | lld:lifeskim |
| pubmed-article:20581821 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20581821 | pubmed:dateCreated | 2010-7-20 | lld:pubmed |
| pubmed-article:20581821 | pubmed:abstractText | The lipocalins are secreted proteins that bind small organic molecules. Scn-Ngal (also known as neutrophil gelatinase associated lipocalin, siderocalin, lipocalin 2) sequesters bacterial iron chelators, called siderophores, and consequently blocks bacterial growth. However, Scn-Ngal is also prominently expressed in aseptic diseases, implying that it binds additional ligands and serves additional functions. Using chemical screens, crystallography and fluorescence methods, we report that Scn-Ngal binds iron together with a small metabolic product called catechol. The formation of the complex blocked the reactivity of iron and permitted its transport once introduced into circulation in vivo. Scn-Ngal then recycled its iron in endosomes by a pH-sensitive mechanism. As catechols derive from bacterial and mammalian metabolism of dietary compounds, the Scn-Ngal-catechol-Fe(III) complex represents an unforeseen microbial-host interaction, which mimics Scn-Ngal-siderophore interactions but instead traffics iron in aseptic tissues. These results identify an endogenous siderophore, which may link the disparate roles of Scn-Ngal in different diseases. | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20581821 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581821 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20581821 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20581821 | pubmed:issn | 1552-4469 | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:MoriKiyoshiK | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:StrongRoland... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:RaymondKennet... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:DengShi-XianS... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:LandryDonald... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:WilliamsDavid... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:BaraschJonath... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:ParagasNealN | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:KalandadzeAvt... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:RatnerAdam... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:PizarroJuan... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:KulkarniRitwi... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:LeeteThomasT | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:QiuAndongA | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:Schmidt-OttKa... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:HoetteTrisha... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:LeeBelindaB | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:ViltardMelani... | lld:pubmed |
| pubmed-article:20581821 | pubmed:author | pubmed-author:LiXiangpoX | lld:pubmed |
