| pubmed-article:20581807 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20581807 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:20581807 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:20581807 | lifeskim:mentions | umls-concept:C0206693 | lld:lifeskim |
| pubmed-article:20581807 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:20581807 | lifeskim:mentions | umls-concept:C2348519 | lld:lifeskim |
| pubmed-article:20581807 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20581807 | pubmed:dateCreated | 2010-10-4 | lld:pubmed |
| pubmed-article:20581807 | pubmed:abstractText | Medullary carcinomas have a better prognosis than other grade 3 mammary carcinomas, but they typically show basal-like biological features, which are associated with a poor prognosis. In this study we examined the associations and prognostic relevance of medullary histological features in a series of 165 invasive carcinomas with a basal-like phenotype: triple-negative (oestrogen receptor, progesterone receptor, HER2) and expressing at least one basal marker (CK5/6, CK14, CK17 or EGFR). The following histological features were associated with each other: prominent inflammation, anastomosing sheets, absence of fibrosis, absence of infiltrative margin and absence of gland formation. Prominent inflammation and anastomosing sheets in at least 30% of the tumour were associated with a better prognosis on univariate analysis. The combination of these two features (a simplified definition of medullary-like type) was present in 17% of tumours and was an independent prognostic factor on multivariate analysis. This simplified definition had good inter-observer reproducibility (?=0.61) and is worthy of more detailed assessment in an unselected group of mammary carcinomas. A fibrotic focus was present in 36% of carcinomas. Only 3% of tumours with a fibrotic focus had features of medullary-like carcinomas. Fibrotic focus of greater than 30% of the tumour was associated with a poor prognosis. This study emphasizes the heterogeneity of morphology and behaviour of triple-negative basal-like carcinomas. | lld:pubmed |
| pubmed-article:20581807 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20581807 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581807 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20581807 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20581807 | pubmed:issn | 1530-0285 | lld:pubmed |
| pubmed-article:20581807 | pubmed:author | pubmed-author:EllisIan OIO | lld:pubmed |
| pubmed-article:20581807 | pubmed:author | pubmed-author:LeeAndrew H... | lld:pubmed |
| pubmed-article:20581807 | pubmed:author | pubmed-author:RakhaEmad AEA | lld:pubmed |
| pubmed-article:20581807 | pubmed:author | pubmed-author:MargineanFeli... | lld:pubmed |
| pubmed-article:20581807 | pubmed:author | pubmed-author:HoBernard CBC | lld:pubmed |
| pubmed-article:20581807 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20581807 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:20581807 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20581807 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20581807 | pubmed:pagination | 1357-63 | lld:pubmed |
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| pubmed-article:20581807 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20581807 | pubmed:articleTitle | Histological features of medullary carcinoma and prognosis in triple-negative basal-like carcinomas of the breast. | lld:pubmed |
| pubmed-article:20581807 | pubmed:affiliation | Department of Histopathology, Nottingham University Hospitals, Nottingham, UK. | lld:pubmed |
| pubmed-article:20581807 | pubmed:publicationType | Journal Article | lld:pubmed |
