| pubmed-article:20581046 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0379710 | lld:lifeskim |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0178784 | lld:lifeskim |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:20581046 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:20581046 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20581046 | pubmed:dateCreated | 2010-8-31 | lld:pubmed |
| pubmed-article:20581046 | pubmed:abstractText | Caveolin-1 belongs to a family of scaffolding proteins, and the P132L point mutation of this gene has been found in up to 16% of all examined breast cancers. Subsequent studies have revealed that the P132L mutation exerts a dominant negative effect through misfolding during caveolin-1 oligomerization. However, this mutation has not been validated in other series of breast cancer samples. Contradictory to the suggested tumor suppressor function, overexpression of caveolin-1 is common in various cancer types. To clarify these inconsistent results, we examined the caveolin-1 mutation in a large series of breast cancer specimens. We first used a standard direct sequencing method and found that none of the 99 breast cancers tested had this mutation. Then we developed a sensitive method for a paraffin section that could detect the mutant allele at a rate of as little as 0.1% among wild-type allele copies. Even when using this sensitive method, none of the 80 estrogen receptor-positive breast tumors had the P132L mutation. Furthermore, 270 cancers in various organs were examined, and no caveolin-1 mutations were detected. These results raise doubt about the presence of the caveolin-1 P132L mutation in breast cancer and other cancer types, and thus further studies are warranted. | lld:pubmed |
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| pubmed-article:20581046 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20581046 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20581046 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20581046 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20581046 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20581046 | pubmed:issn | 1943-7811 | lld:pubmed |
| pubmed-article:20581046 | pubmed:author | pubmed-author:NakaoAkimasaA | lld:pubmed |
| pubmed-article:20581046 | pubmed:author | pubmed-author:KoderaYasuhir... | lld:pubmed |
| pubmed-article:20581046 | pubmed:author | pubmed-author:YatabeYasushi... | lld:pubmed |
| pubmed-article:20581046 | pubmed:author | pubmed-author:IwataHirojiH | lld:pubmed |
| pubmed-article:20581046 | pubmed:author | pubmed-author:KoikeShinyaS | lld:pubmed |
| pubmed-article:20581046 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20581046 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:20581046 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20581046 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20581046 | pubmed:pagination | 712-7 | lld:pubmed |
| pubmed-article:20581046 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
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| pubmed-article:20581046 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20581046 | pubmed:articleTitle | Absence of the caveolin-1 P132L mutation in cancers of the breast and other organs. | lld:pubmed |
| pubmed-article:20581046 | pubmed:affiliation | Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Chikusa-ku, Nagoya, Japan. | lld:pubmed |
| pubmed-article:20581046 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20581046 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:857 | entrezgene:pubmed | pubmed-article:20581046 | lld:entrezgene |
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