Linked Life Data

20575990

Source:http://linkedlifedata.com/resource/pubmed/id/20575990

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pubmed-article:20575990pubmed:abstractTextSalmonella enterica serovar Typhimurium (S. typhimurium) causes a localized enteric infection and its elimination is dependent on a T helper type 1 immune response. However, the mechanism of the protective immune response against the pathogen in gut-associated lymphoid tissue (GALT) at an early stage of the infection is not yet clarified. Here, we show that interleukin-17A (IL-17A) was constitutively expressed in GALT; it was also detected on crypt and epithelial cells of the small intestine. Neutralization of the IL-17A in the intestinal lumen exacerbated epithelial damage induced by intestinal S. typhimurium infection at an early stage of the infection. The result suggests that IL-17A has a pivotal role in the immediate early stage of protection against bacterial infection at the intestinal mucosa. As IL-17A neutralization also suppressed the constitutive localization of ?-defensin 3 (BD3), an IL-17A-induced antimicrobial peptide, at the apical site of the intestinal mucosa, it is estimated that IL-17A constitutively induces the expression of the antimicrobial peptide to kill invading pathogens at the epithelial surface immediately after the infection. In contrast, interferon-? is induced around 3 days after S. typhimurium infection, and its expression level increases thereafter. Taken together, the findings lead to the hypothesis that IL-17A participates in the immediate early stage of protection against S. typhimurium intestinal infection whereas interferon-? is important at a later stage of the infection.lld:pubmed
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pubmed-article:20575990pubmed:authorpubmed-author:OkamotoYukoYlld:pubmed
pubmed-article:20575990pubmed:authorpubmed-author:MatsuzakiGoro...lld:pubmed
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pubmed-article:20575990pubmed:authorpubmed-author:Inagaki-Ohara...lld:pubmed
pubmed-article:20575990pubmed:authorpubmed-author:MayuzumiHirok...lld:pubmed
pubmed-article:20575990pubmed:copyrightInfo© 2010 The Authors. Immunology © 2010 Blackwell Publishing Ltd.lld:pubmed
pubmed-article:20575990pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20575990pubmed:volume131lld:pubmed
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pubmed-article:20575990pubmed:pagination377-85lld:pubmed
pubmed-article:20575990pubmed:dateRevised2011-11-1lld:pubmed
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pubmed-article:20575990pubmed:year2010lld:pubmed
pubmed-article:20575990pubmed:articleTitleInterleukin-17A is required to suppress invasion of Salmonella enterica serovar Typhimurium to enteric mucosa.lld:pubmed
pubmed-article:20575990pubmed:affiliationCenter of Molecular Biosciences, Tropical Biosphere Research Centre, University of the Ryukyus, Senbaru, Nishihara, Okinawa, Japan.lld:pubmed
pubmed-article:20575990pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20575990pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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