| pubmed-article:20574539 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0025933 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C1421319 | lld:lifeskim |
| pubmed-article:20574539 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20574539 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20574539 | pubmed:dateCreated | 2010-6-24 | lld:pubmed |
| pubmed-article:20574539 | pubmed:abstractText | Obesity is characterized by the accumulation of fat in the liver and other tissues, leading to insulin resistance. We have previously shown that a specific inhibitor of glucosylceramide synthase, which inhibits the initial step in the synthesis of glycosphingolipids (GSLs), improved glucose metabolism and decreased hepatic steatosis in both ob/ob and diet-induced obese (DIO) mice. Here we have determined in the DIO mouse model the efficacy of a related small molecule compound, Genz-112638, which is currently being evaluated clinically for the treatment of Gaucher disease, a lysosomal storage disorder. | lld:pubmed |
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| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20574539 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20574539 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20574539 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20574539 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20574539 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20574539 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20574539 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:ShaymanJames... | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:JiangCanwenC | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:ChengSeng HSH | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:KimJason KJK | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:YewNelson SNS | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:ZhaoHongmeiH | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:PrzybylskaMal... | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:WuI-HuanIH | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:ArbeenyCynthi... | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:HongEun-Gyoun... | lld:pubmed |
| pubmed-article:20574539 | pubmed:author | pubmed-author:SiegelCraigC | lld:pubmed |
| pubmed-article:20574539 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20574539 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20574539 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20574539 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20574539 | pubmed:pagination | e11239 | lld:pubmed |
| pubmed-article:20574539 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20574539 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20574539 | pubmed:articleTitle | Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase. | lld:pubmed |
| pubmed-article:20574539 | pubmed:affiliation | Genzyme Corporation, Framingham, Massachusetts, USA. nelson.yew@genzyme.com | lld:pubmed |
| pubmed-article:20574539 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20574539 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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