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pubmed-article:20572672pubmed:abstractTextAn integrated set of reactions and conditions that allow an eight-step one-flask synthesis of the protected derivatives of c-di-GMP and the [R(p),R(p)] and [R(p),S(p)] thiophosphate analogues is reported. Deprotection is also carried out as a one-flask procedure, with the final products isolated by crystallization from the reaction mixture. Chromatography is only used for separation of the thiophosphate diastereomers.lld:pubmed
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pubmed-article:20572672pubmed:authorpubmed-author:ZhaoJianweiJlld:pubmed
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pubmed-article:20572672pubmed:dateRevised2011-8-1lld:pubmed
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pubmed-article:20572672pubmed:articleTitleOne-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues.lld:pubmed
pubmed-article:20572672pubmed:affiliationDepartment of Chemistry and Chemical Biology, 610 Taylor Road, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA.lld:pubmed
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