| pubmed-article:20570685 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C0040732 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C1563739 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C0237677 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C0015252 | lld:lifeskim |
| pubmed-article:20570685 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:20570685 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20570685 | pubmed:dateCreated | 2010-7-27 | lld:pubmed |
| pubmed-article:20570685 | pubmed:abstractText | Increases in intra-abdominal fat, a common feature associated with aging, is an established risk factor for insulin resistance, diabetes and the metabolic syndrome. To examine the direct contribution of intra-abdominal fat in the pathophysiology of insulin resistance we altered fat volume via removal or transplantation in a naturally occurring age-induced moderate model of obesity and insulin resistance. This was accomplished by bilateral removal of epididymal white adipose tissue (Lipx) or transplantation of donor fat into the intra-abdominal side of the peritoneal cavity of 28-week old rats. Control animals received sham surgery. Glucose tolerance was evaluated at baseline and 4 and 8weeks post-surgery in all groups, and fasting insulin and leptin were additionally measured in 28-week old rats. In addition, fasted and fed triglyceride, cholesterol and fatty acid concentrations were measured. Before surgery 28-week old rats weighed more and were glucose intolerant compared with 8-week old controls. Both Lipx and transplantation significantly prevented age-induced decreases in glucose tolerance, with Lipx causing improvement at 4weeks which declined by 8weeks; and with a significant transplantation improvement at 8weeks only. Lipx significantly increased insulin secretion 15min after a bolus injection of 0.75mg/kg dextrose at 4 and 8weeks compared with controls, while transplantation caused a significant ( approximately 220%) increase in fasted leptin level at 4weeks only. Taken together, these data suggest that surgical removal or addition of intra-abdominal fat prevents age-induced insulin resistance by different mechanisms and is a suitable model to investigate naturally occurring obesity. | lld:pubmed |
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| pubmed-article:20570685 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20570685 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20570685 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20570685 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20570685 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20570685 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20570685 | pubmed:issn | 1873-507X | lld:pubmed |
| pubmed-article:20570685 | pubmed:author | pubmed-author:WoodsStephen... | lld:pubmed |
| pubmed-article:20570685 | pubmed:author | pubmed-author:SeeleyRandy... | lld:pubmed |
| pubmed-article:20570685 | pubmed:author | pubmed-author:ShiHaifeiH | lld:pubmed |
| pubmed-article:20570685 | pubmed:author | pubmed-author:FosterMichell... | lld:pubmed |
| pubmed-article:20570685 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20570685 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20570685 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20570685 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:20570685 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20570685 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20570685 | pubmed:pagination | 282-8 | lld:pubmed |
| pubmed-article:20570685 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:20570685 | pubmed:meshHeading | pubmed-meshheading:20570685... | lld:pubmed |
| pubmed-article:20570685 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20570685 | pubmed:articleTitle | Transplantation or removal of intra-abdominal adipose tissue prevents age-induced glucose insensitivity. | lld:pubmed |
| pubmed-article:20570685 | pubmed:affiliation | Obesity Research Center, Department of Psychiatry, University of Cincinnati, 2170 E. Galbraith Road, Cincinnati, OH 45237, United States. Michelle.Foster@uc.edu | lld:pubmed |
| pubmed-article:20570685 | pubmed:publicationType | Journal Article | lld:pubmed |
