| pubmed-article:20558942 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20558942 | lifeskim:mentions | umls-concept:C0346421 | lld:lifeskim |
| pubmed-article:20558942 | lifeskim:mentions | umls-concept:C0034902 | lld:lifeskim |
| pubmed-article:20558942 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:20558942 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20558942 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:20558942 | pubmed:dateCreated | 2010-6-18 | lld:pubmed |
| pubmed-article:20558942 | pubmed:abstractText | A 28-year-old man with marked eosinophilia is described. FIP1L1/PDGFRA mRNA showed multiple alternatively-spliced fusion transcripts. Sequencing analysis showed that the deduced DNA breakpoints were intron 10 in the FIP1L1 gene and exon 12 in the PDGFRA gene. Then, a diagnosis of chronic eosinophilic leukemia (CEL) was made. Whereas the response to the treatments with prednisolone and hydroxyurea were unsatisfactory, treatment with imatinib showed a rapid decrease of eosinophils. The hemoglobin level also dropped and bone marrow examination showed pure red cell aplasia. Continued administration of very low dose imatinib (100 mg every 5 days) led to and maintained complete molecular remission, with good tolerability. | lld:pubmed |
| pubmed-article:20558942 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20558942 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20558942 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20558942 | pubmed:issn | 1349-7235 | lld:pubmed |
| pubmed-article:20558942 | pubmed:author | pubmed-author:AsouHiroyaH | lld:pubmed |
| pubmed-article:20558942 | pubmed:author | pubmed-author:KimuraAkiroA | lld:pubmed |
| pubmed-article:20558942 | pubmed:author | pubmed-author:IwatoKojiK | lld:pubmed |
| pubmed-article:20558942 | pubmed:author | pubmed-author:TanakaHideoH | lld:pubmed |
| pubmed-article:20558942 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20558942 | pubmed:volume | 49 | lld:pubmed |
| pubmed-article:20558942 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20558942 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20558942 | pubmed:pagination | 1195-200 | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:meshHeading | pubmed-meshheading:20558942... | lld:pubmed |
| pubmed-article:20558942 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20558942 | pubmed:articleTitle | Pure red cell aplasia associated with imatinib-treated FIP1L1-PDGFRA positive chronic eosinophilic leukemia. | lld:pubmed |
| pubmed-article:20558942 | pubmed:affiliation | Department of Hematology, Hiroshima City Asa Hospital, Hiroshima, Japan. | lld:pubmed |
| pubmed-article:20558942 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20558942 | pubmed:publicationType | Case Reports | lld:pubmed |
