pubmed-article:20554764 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20554764 | lifeskim:mentions | umls-concept:C1166758 | lld:lifeskim |
pubmed-article:20554764 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
pubmed-article:20554764 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
pubmed-article:20554764 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
pubmed-article:20554764 | lifeskim:mentions | umls-concept:C0182953 | lld:lifeskim |
pubmed-article:20554764 | pubmed:issue | 15 | lld:pubmed |
pubmed-article:20554764 | pubmed:dateCreated | 2010-7-30 | lld:pubmed |
pubmed-article:20554764 | pubmed:abstractText | Functional analysis of cytoplasmic dynein in Caenorhabditis elegans has revealed a wide range of cellular functions for this minus-end-directed motor protein. Dynein transports a variety of cargos to diverse cellular locations, and thus cargo selection and destination are likely regulated by accessory proteins. The microtubule-associated proteins LIS-1 and dynein interact, but the nature of this interaction remains poorly understood. Here we show that both LIS-1 and the dynein heavy-chain DHC-1 are required for integrity of the actin cytoskeleton in C. elegans. Although both dhc-1(or195ts) and lis-1 loss-of-function disrupt the actin cytoskeleton and produce embryonic lethality, a double mutant suppresses these defects. A targeted RNA interference screen revealed that knockdown of other actin regulators, including actin-capping protein genes and prefoldin subunit genes, suppresses dhc-1(or195ts)-induced lethality. We propose that release or relocation of the mutant dynein complex mediates this suppression of dhc-1(or195ts)-induced phenotypes. These results reveal an unexpected direct or indirect interaction between the actin cytoskeleton and dynein activity. | lld:pubmed |
pubmed-article:20554764 | pubmed:language | eng | lld:pubmed |
pubmed-article:20554764 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20554764 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20554764 | pubmed:month | Aug | lld:pubmed |
pubmed-article:20554764 | pubmed:issn | 1939-4586 | lld:pubmed |
pubmed-article:20554764 | pubmed:author | pubmed-author:HunterCraig... | lld:pubmed |
pubmed-article:20554764 | pubmed:author | pubmed-author:ButtnerEdgar... | lld:pubmed |
pubmed-article:20554764 | pubmed:author | pubmed-author:Gil-KrzewskaA... | lld:pubmed |
pubmed-article:20554764 | pubmed:author | pubmed-author:FarberEricaE | lld:pubmed |
pubmed-article:20554764 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20554764 | pubmed:day | 1 | lld:pubmed |
pubmed-article:20554764 | pubmed:volume | 21 | lld:pubmed |
pubmed-article:20554764 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20554764 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20554764 | pubmed:pagination | 2707-20 | lld:pubmed |
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pubmed-article:20554764 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:20554764 | pubmed:articleTitle | Regulators of the actin cytoskeleton mediate lethality in a Caenorhabditis elegans dhc-1 mutant. | lld:pubmed |
pubmed-article:20554764 | pubmed:affiliation | Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. | lld:pubmed |
pubmed-article:20554764 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:20554764 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20554764 | lld:entrezgene |