| pubmed-article:20547682 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20547682 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:20547682 | lifeskim:mentions | umls-concept:C0030054 | lld:lifeskim |
| pubmed-article:20547682 | lifeskim:mentions | umls-concept:C0470187 | lld:lifeskim |
| pubmed-article:20547682 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20547682 | pubmed:issue | Pt 16 | lld:pubmed |
| pubmed-article:20547682 | pubmed:dateCreated | 2010-8-16 | lld:pubmed |
| pubmed-article:20547682 | pubmed:abstractText | beta-Adrenoceptors (beta-ARs) play a critical role in the regulation of cardiovascular function. Intracellular oxygen homeostasis is crucial for the survival of cardiomyocytes. However, it is still unclear whether beta-AR activation can modulate intracellular oxygen. Here we used mitochondrial and cytosolic target Renilla luciferase to detect intracellular oxygen concentration. Pharmacological experiments revealed that beta2-AR activation specifically regulates intracellular oxygen in cardiomyocytes and COS7 cells. This effect was abrogated by inhibitory G protein (Gi) inhibition, endothelial nitric oxide synthase (eNOS) blockade, and NO scavenging, implicating that the beta2-AR-Gi-eNOS pathway is involved in this regulation. beta2-AR activation increased the AMP/ATP ratio, AMPK activity, ROS production and prolyl hydroxylase activity. These effects also contribute to the regulation of beta2-AR signalling, thus providing an additional layer of complexity to enforce the specificity of beta1-AR and beta2-AR signalling. Collectively, the study provides novel insight into the modulation of oxygen homeostasis, broadens the scope of beta2-AR function, and may have crucial implications for beta2-AR signalling regulation. | lld:pubmed |
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| pubmed-article:20547682 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20547682 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20547682 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20547682 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20547682 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20547682 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20547682 | pubmed:issn | 1469-7793 | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:MeeSS | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:LiuYingY | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:LiuYiY | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:ZhouZhao-Nian... | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:ShiJingyiJ | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:CuiJianminJ | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:ZhangYouyiY | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:PengLuyingL | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:ChenYi-HanYH | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:XuJiahongJ | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:ASISOO | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:SunYunfuY | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:LiangDandanD | lld:pubmed |
| pubmed-article:20547682 | pubmed:author | pubmed-author:HuoZhaoxiaZ | lld:pubmed |
| pubmed-article:20547682 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20547682 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20547682 | pubmed:volume | 588 | lld:pubmed |
| pubmed-article:20547682 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20547682 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20547682 | pubmed:pagination | 2987-98 | lld:pubmed |
| pubmed-article:20547682 | pubmed:dateRevised | 2011-8-25 | lld:pubmed |
| pubmed-article:20547682 | pubmed:meshHeading | pubmed-meshheading:20547682... | lld:pubmed |
