Linked Life Data

20547440

Source:http://linkedlifedata.com/resource/pubmed/id/20547440

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pubmed-article:20547440pubmed:abstractTextAurora-A (Aur-A) is a centrosome-associated serine/threonine kinase that is overexpressed in various cancers and potentially correlated with chemoresistance. In the Ara-C-sensitive leukemia cell lines, silencing of Aur-A by small interfering RNA transfection led to a significant increase in the Ara-C-induced cell death rate through induction of mitochondria-mediated, caspase-dependent apoptosis. In contrast, combined treatment of the Ara-C-resistant leukemia cell lines with Aur-A siRNA and Ara-C remarkably enhanced the cell death rate via non-caspase-dependent mitotic catastrophe. Taken together, Aur-A inhibition was an effective treatment for both the Ara-C-sensitive and resistant leukemia cells by increasing apoptosis and mitotic catastrophe, respectively.lld:pubmed
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pubmed-article:20547440pubmed:authorpubmed-author:KimSoo JungSJlld:pubmed
pubmed-article:20547440pubmed:authorpubmed-author:MinYoo HongYHlld:pubmed
pubmed-article:20547440pubmed:authorpubmed-author:CheongJune-Wo...lld:pubmed
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pubmed-article:20547440pubmed:authorpubmed-author:EomJu InJIlld:pubmed
pubmed-article:20547440pubmed:authorpubmed-author:JeungHoi-Kyun...lld:pubmed
pubmed-article:20547440pubmed:copyrightInfoCopyright © 2010 Elsevier Ireland Ltd. All rights reserved.lld:pubmed
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pubmed-article:20547440pubmed:pagination171-81lld:pubmed
pubmed-article:20547440pubmed:dateRevised2011-7-11lld:pubmed
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pubmed-article:20547440pubmed:year2010lld:pubmed
pubmed-article:20547440pubmed:articleTitleAurora-A kinase inhibition enhances the cytosine arabinoside-induced cell death in leukemia cells through apoptosis and mitotic catastrophe.lld:pubmed
pubmed-article:20547440pubmed:affiliationDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.lld:pubmed
pubmed-article:20547440pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20547440pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed