| pubmed-article:20534506 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C0312359 | lld:lifeskim |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C0024429 | lld:lifeskim |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C1334507 | lld:lifeskim |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20534506 | lifeskim:mentions | umls-concept:C0123047 | lld:lifeskim |
| pubmed-article:20534506 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:20534506 | pubmed:dateCreated | 2010-6-23 | lld:pubmed |
| pubmed-article:20534506 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:abstractText | AV411 (ibudilast; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine) is an antiinflammatory drug that was initially developed for the treatment of bronchial asthma but which also has been used for cerebrovascular and ocular indications. It is a nonselective inhibitor of various phosphodiesterases (PDEs) and has varied antiinflammatory activity. More recently, AV411 has been studied as a possible therapeutic for the treatment of neuropathic pain and opioid withdrawal through its actions on glial cells. As described herein, the PDE inhibitor AV411 and its PDE-inhibition-compromised analog AV1013 inhibit the catalytic and chemotactic functions of the proinflammatory protein, macrophage migration inhibitory factor (MIF). Enzymatic analysis indicates that these compounds are noncompetitive inhibitors of the p-hydroxyphenylpyruvate (HPP) tautomerase activity of MIF and an allosteric binding site of AV411 and AV1013 is detected by NMR. The allosteric inhibition mechanism is further elucidated by X-ray crystallography based on the MIF/AV1013 binary and MIF/AV1013/HPP ternary complexes. In addition, our antibody experiments directed against MIF receptors indicate that CXCR2 is the major receptor for MIF-mediated chemotaxis of peripheral blood mononuclear cells. | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20534506 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20534506 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20534506 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20534506 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:LüZ BZB | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:JohnsonKirkK | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:CappelloMicha... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:BucalaRichard... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:HodsdonMichae... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:CrichlowGregg... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:LengLinL | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:ChoYoonsangY | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:GrossMattM | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:VermeireJon... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:LolisElias... | lld:pubmed |
| pubmed-article:20534506 | pubmed:author | pubmed-author:GaetaFederico... | lld:pubmed |
| pubmed-article:20534506 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20534506 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:20534506 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20534506 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20534506 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20534506 | pubmed:pagination | 11313-8 | lld:pubmed |
| pubmed-article:20534506 | pubmed:dateRevised | 2011-11-10 | lld:pubmed |
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| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
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| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
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| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:meshHeading | pubmed-meshheading:20534506... | lld:pubmed |
| pubmed-article:20534506 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20534506 | pubmed:articleTitle | Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast. | lld:pubmed |
| pubmed-article:20534506 | pubmed:affiliation | Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06510, USA. | lld:pubmed |
| pubmed-article:20534506 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20534506 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20534506 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:4282 | entrezgene:pubmed | pubmed-article:20534506 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20534506 | lld:entrezgene |
