| pubmed-article:20532182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0012920 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0146224 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:20532182 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20532182 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20532182 | pubmed:dateCreated | 2010-6-10 | lld:pubmed |
| pubmed-article:20532182 | pubmed:abstractText | Human topoisomerase I catalyzes the relaxation of DNA supercoils in fundamental cell processes like transcription, replication and chromosomal segregation. It is the only target of the camptothecin family of anticancer drugs. Among these, topotecan has been used to treat lung and ovarian carcinoma for several years. Camptothecins reversibly binds to the covalent intermediate DNA-enzyme, stabilizing the cleavable complex and reducing the religation rate. The stalled complex then collides with the progression of the replication fork, producing lethal double strand DNA breaks and eventually cell death. | lld:pubmed |
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| pubmed-article:20532182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20532182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20532182 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20532182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20532182 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:ChillemiGiova... | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:SannaNicoN | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:DesideriAless... | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:ManciniGiorda... | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:D'AnnessaIlda... | lld:pubmed |
| pubmed-article:20532182 | pubmed:author | pubmed-author:ColettaAndrea... | lld:pubmed |
| pubmed-article:20532182 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20532182 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20532182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20532182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20532182 | pubmed:pagination | e10934 | lld:pubmed |
| pubmed-article:20532182 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:meshHeading | pubmed-meshheading:20532182... | lld:pubmed |
| pubmed-article:20532182 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20532182 | pubmed:articleTitle | Structural and dynamical effects induced by the anticancer drug topotecan on the human topoisomerase I - DNA complex. | lld:pubmed |
| pubmed-article:20532182 | pubmed:affiliation | CASPUR Inter-University Consortium for the Application of Super-Computing for Universities and Research, Rome, Italy. | lld:pubmed |
| pubmed-article:20532182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20532182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
