| pubmed-article:2052609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C1739664 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:2052609 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:2052609 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:2052609 | pubmed:dateCreated | 1991-7-19 | lld:pubmed |
| pubmed-article:2052609 | pubmed:abstractText | Stable transformants of the Jurkat T-cell line have been obtained that express either of two distinct forms of the type 1 human immunodeficiency virus nef gene: the nef-1-encoded protein (Nef-1) contains alanine, glycine, and valine at positions 15, 29, and 33, respectively; the protein specified by nef-2 (Nef-2) has threonine, arginine, and alanine at the corresponding positions. When Jurkat cells or their Nef-2-expressing transformants are treated with phorbol 12-myristate 13-acetate (PMA) plus either phytohemagglutinin (PHA) or antibodies against CD3 epsilon, T-cell receptor beta chain, or CD2, there is a prompt increase in interleukin 2 (IL-2) mRNA and intracellular calcium and in the IL-2 receptor alpha chain on the cell surface. Although cells expressing Nef-1 also induce calcium mobilization and the production of IL-2 receptor alpha chain, the formation of IL-2 mRNA is blocked in response to these stimuli. Moreover, Nef-1-expressing cells transfected with a plasmid in which the IL-2 promoter is fused to the chloramphenicol acetyltransferase (CAT) gene fail to induce CAT following treatment with PMA and PHA. By contrast, the parental and Nef-2-containing cells induce CAT normally. Nef-1-expressing cells can produce IL-2 mRNA in response to a combination of PMA and ionomycin, although much less efficiently than the parental Jurkat cells or Nef-2-expressing cells. These findings, and others described herein, suggest that the virally encoded Nef protein interferes with a signal emanating from the T-cell receptor complex that induces IL-2 gene transcription. | lld:pubmed |
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| pubmed-article:2052609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2052609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2052609 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2052609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2052609 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2052609 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2052609 | pubmed:author | pubmed-author:BergPP | lld:pubmed |
| pubmed-article:2052609 | pubmed:author | pubmed-author:LurieWW | lld:pubmed |
| pubmed-article:2052609 | pubmed:author | pubmed-author:ChambersII | lld:pubmed |
| pubmed-article:2052609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2052609 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:2052609 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:2052609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2052609 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2052609 | pubmed:pagination | 5326-30 | lld:pubmed |
| pubmed-article:2052609 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
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| pubmed-article:2052609 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2052609 | pubmed:articleTitle | Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. | lld:pubmed |
| pubmed-article:2052609 | pubmed:affiliation | Department of Biochemistry, Beckman Center, Stanford University Medical Center, CA 94305. | lld:pubmed |
| pubmed-article:2052609 | pubmed:publicationType | Journal Article | lld:pubmed |
