| pubmed-article:20515692 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0003069 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0043457 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C1185749 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0013936 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0332285 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0234388 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:20515692 | lifeskim:mentions | umls-concept:C1706701 | lld:lifeskim |
| pubmed-article:20515692 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20515692 | pubmed:dateCreated | 2010-8-16 | lld:pubmed |
| pubmed-article:20515692 | pubmed:abstractText | There are multiple populations of gonadotropin-releasing hormone (GnRH) neurons that have distinct physiological and behavioral functions. Teleost fish have a population of GnRH3 neurons located in the terminal nerve (TN) associated with the olfactory bulb that is thought to play a neuromodulatory role in multiple physiological systems, including olfactory, visual, and reproductive. We used transgenic zebrafish in which the GnRH3 promoter drives expression of a green fluorescent protein to identify GnRH3 neurons during development in live embryos. Unlike with hypophysiotropic GnRH neurons of zebrafish, TN-GnRH3 neurons are of neural crest origin and are one of the first populations of GnRH neurons to develop in the early embryo. Using a combination of optical imaging and electrophysiology, we showed that during the first 3 days post-fertilization, TN-GnRH3 neurons increase in number, extend neural projections, move in association with tissue expansion, and acquire an adult-pattern of spontaneous action potential firing. Early during development, about half of the neurons were quiescent/non-firing. Later, at 3 days post-fertilization, there was an increase in the proportion of neurons showing action potential firing and an increase in the number of neurons that showed an adult-like tonic or beating pattern of action potential firing with a firing frequency similar to that seen in adult TN-GnRH3 neurons. This study represents the first neurophysiological investigation of developing GnRH neurons in live embryos--an important advancement in understanding their potential non-reproductive roles during embryogenesis. | lld:pubmed |
| pubmed-article:20515692 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20515692 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20515692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20515692 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20515692 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20515692 | pubmed:issn | 1095-6840 | lld:pubmed |
| pubmed-article:20515692 | pubmed:author | pubmed-author:WayneNancy... | lld:pubmed |
| pubmed-article:20515692 | pubmed:author | pubmed-author:LeeWenjauW | lld:pubmed |
| pubmed-article:20515692 | pubmed:author | pubmed-author:KozlowskiDavi... | lld:pubmed |
| pubmed-article:20515692 | pubmed:author | pubmed-author:NavarreSammyS | lld:pubmed |
| pubmed-article:20515692 | pubmed:author | pubmed-author:RamakrishnanS... | lld:pubmed |
| pubmed-article:20515692 | pubmed:copyrightInfo | Copyright (c) 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20515692 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20515692 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20515692 | pubmed:volume | 168 | lld:pubmed |
| pubmed-article:20515692 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20515692 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20515692 | pubmed:pagination | 401-7 | lld:pubmed |
| pubmed-article:20515692 | pubmed:dateRevised | 2011-9-19 | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:meshHeading | pubmed-meshheading:20515692... | lld:pubmed |
| pubmed-article:20515692 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20515692 | pubmed:articleTitle | Acquisition of spontaneous electrical activity during embryonic development of gonadotropin-releasing hormone-3 neurons located in the terminal nerve of transgenic zebrafish (Danio rerio). | lld:pubmed |
| pubmed-article:20515692 | pubmed:affiliation | Department of Physiology, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, United States. | lld:pubmed |
| pubmed-article:20515692 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20515692 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:20515692 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20515692 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:360141 | entrezgene:pubmed | pubmed-article:20515692 | lld:entrezgene |
