| pubmed-article:20514414 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C0001430 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C0025241 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C2745888 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20514414 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20514414 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20514414 | pubmed:dateCreated | 2010-6-1 | lld:pubmed |
| pubmed-article:20514414 | pubmed:abstractText | In previous research, we focused on the discovery of K-ras biomarkers, and effects of genotoxic carcinogens on their expression were investigated in this study. It is well-known that mutated K-ras gene is involved in approximately 30% of human cancers such as lung cancer. To search for K-ras oncogene-induced modulators in lung tissues of K-ras transgenic mice, we analyzed K-ras-specific genes and proteins related to cancer development, signal transduction, inflammation as well as tumor suppression in a previous study. In this study, we investigated the modulating effects of genotoxic carcinogen treatment on expression of K-ras-dependent modulated genes and proteins in lung tissues of K-ras Tg mice. In order to evaluate candidate K-ras markers modulated by genotoxic stress and to investigate whether a genotoxic carcinogen would enhance or inhibit carcinogenesis in lung tissues of the K-ras Tg mice, the anti-cancer drug melphalan was intraperitoneally injected into K-ras Tg mice every two days for four weeks. RT-qPCR and proteomics analyses were performed in order to confirm whether K-ras-specific biomarkers would be modulated by melphalan treatment in K-ras Tg mice. The decreased adenomas were histopathologically observed and K-ras expression was suppressed in melphalan-treated K-ras Tg mice. Melphalan also recovered the expression of K-ras-dependent modulated biomarkers. These results suggest that melphalan inhibits carcinogenesis via modulating K-ras-specific genes and proteins expressed in the lung tissues of K-ras Tg mice. | lld:pubmed |
| pubmed-article:20514414 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20514414 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20514414 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20514414 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20514414 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20514414 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20514414 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20514414 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20514414 | pubmed:issn | 1791-2423 | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:YuDae-YeulDY | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:YoonDo-YoungD... | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:KimHeejongH | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:ParkYoung-HoY... | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:ParkSue-NieSN | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:LeeSojungS | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:KimEunjinE | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:KimJinmanJ | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:ChoiHeesookH | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:YoonSeok-JooS... | lld:pubmed |
| pubmed-article:20514414 | pubmed:author | pubmed-author:SheenYhunyhon... | lld:pubmed |
| pubmed-article:20514414 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20514414 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:20514414 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20514414 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20514414 | pubmed:pagination | 219-28 | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
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| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:meshHeading | pubmed-meshheading:20514414... | lld:pubmed |
| pubmed-article:20514414 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20514414 | pubmed:articleTitle | Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice. | lld:pubmed |
| pubmed-article:20514414 | pubmed:affiliation | Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Hwayang-dong 1, Gwangjin-gu, Seoul 143-701, Korea. | lld:pubmed |
| pubmed-article:20514414 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20514414 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:16653 | entrezgene:pubmed | pubmed-article:20514414 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20514414 | lld:entrezgene |
