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pubmed-article:20512334pubmed:abstractTextPaclitaxel (PACL) plus gemcitabine (GEM) is an effective regimen for advanced breast cancer patients pretreated with anthracyclines. A prolonged GEM infusion at a fixed dose rate (FDR) of 10 mg/m²/min produces higher levels of intracellular active metabolites of GEM when compared with a standard 30-min infusion. In the present phase I/II trial, we investigated the association of FDR GEM plus PACL.lld:pubmed
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pubmed-article:20512334pubmed:articleTitlePhase I-II trial of prolonged gemcitabine infusion plus paclitaxel as a biweekly schedule for advanced breast cancer patients pretreated with anthracyclines.lld:pubmed
pubmed-article:20512334pubmed:affiliationDepartment of Medical Oncology, Regina Elena Cancer Institute, Rome, Italy. pvici@ifo.itlld:pubmed
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