| pubmed-article:20508868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20508868 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20508868 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20508868 | lifeskim:mentions | umls-concept:C0209368 | lld:lifeskim |
| pubmed-article:20508868 | lifeskim:mentions | umls-concept:C0599918 | lld:lifeskim |
| pubmed-article:20508868 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20508868 | pubmed:dateCreated | 2010-5-28 | lld:pubmed |
| pubmed-article:20508868 | pubmed:abstractText | In the present study the effect of mycophenolate mofetil (MMF), an immunosuppressant, on mercuric chloride (HgCl(2))-induced nephrotoxicity in male Wistar rats was investigated. Animals (200-250 g) were divided into five groups and were subjected to a 6-day treatment schedule. The first (control) group received only vehicle without any active drug. The second to fifth groups were administered HgCl(2) challenge (single dose of 5 mg/kg, s.c.) on the fourth day. Additionally, the second group received distilled water (DW) on all 6 days and the third group was administered DW the initial 3 days and MMF (10 mg/kg b.i.d. by oral gavage) on days 4-6. The fourth group was given DW the initial 2 days and MMF on days 3-6 and the fifth group received MMF all 6 days. All animals were euthanized on the sixth day. It was found that HgCl(2) administration caused significant nephrotoxicity, as indicated by a rise in serum creatinine, blood urea and soluble intercellular adhesion molecule 1 (sICAM-1) concentrations, histopathological injury and increased oxidative stress (altered malondialdehyde and glutathione levels) as compared to the control group. Administration of MMF significantly ameliorated HgCl(2)-induced nephrotoxicity. The results suggest the potential of MMF in preventing the acute nephrotoxicity of HgCl(2). | lld:pubmed |
| pubmed-article:20508868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20508868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20508868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20508868 | pubmed:month | May | lld:pubmed |
| pubmed-article:20508868 | pubmed:issn | 0379-0355 | lld:pubmed |
| pubmed-article:20508868 | pubmed:author | pubmed-author:DindaA KAK | lld:pubmed |
| pubmed-article:20508868 | pubmed:author | pubmed-author:GuptaY KYK | lld:pubmed |
| pubmed-article:20508868 | pubmed:author | pubmed-author:ReetaK HKH | lld:pubmed |
| pubmed-article:20508868 | pubmed:author | pubmed-author:SarangiS CSC | lld:pubmed |
| pubmed-article:20508868 | pubmed:copyrightInfo | Copyright 2010 Prous Science, S.A.U. or its licensors. All rights reserved. | lld:pubmed |
| pubmed-article:20508868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:20508868 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:20508868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20508868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20508868 | pubmed:pagination | 219-25 | lld:pubmed |
| pubmed-article:20508868 | pubmed:meshHeading | pubmed-meshheading:20508868... | lld:pubmed |
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| pubmed-article:20508868 | pubmed:meshHeading | pubmed-meshheading:20508868... | lld:pubmed |
| pubmed-article:20508868 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20508868 | pubmed:articleTitle | Protective effect of mycophenolate mofetil on mercuric chloride-induced nephrotoxicity in rats. | lld:pubmed |
| pubmed-article:20508868 | pubmed:affiliation | Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. | lld:pubmed |
| pubmed-article:20508868 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:25464 | entrezgene:pubmed | pubmed-article:20508868 | lld:entrezgene |
