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pubmed-article:20506137pubmed:abstractTextSmad3 (or, MADH3) is a key intracellular messenger in the transforming growth factor beta signaling pathway. In mice, Smad3 deficiency accelerates growth plate chondrocyte maturation and leads to an osteoarthritis (OA)-like disease. We undertook this study to investigate the role of genetic variation in SMAD3 in the risk of large-joint OA in humans.lld:pubmed
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pubmed-article:20506137pubmed:articleTitleGenetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.lld:pubmed
pubmed-article:20506137pubmed:affiliationDepartment of Twin Research and Genetic Epidemiology, St. Thomas' Hospital Campus, King's College London, London SE1 7EH, UK. ana.valdes@kcl.ac.uklld:pubmed
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