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pubmed-article:20504318pubmed:abstractTextThe phylogenetic position of the elephant shark (Callorhinchus milii ) is particularly relevant to study the evolution of genes and gene regulation in vertebrates. Here we examine the evolution of Dlx homeobox gene regulation during vertebrate embryonic development with a particular focus on the forebrain. We first identified the elephant shark sequence orthologous to the URE2 cis -regulatory element of the mouse Dlx1/Dlx2 locus (herein named CmURE2). We then conducted a comparative study of the sequence and enhancer activity of CmURE2 with that of orthologous regulatory sequences from zebrafish and mouse.lld:pubmed
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pubmed-article:20504318pubmed:articleTitleFunctional conservation of a forebrain enhancer from the elephant shark (Callorhinchus milii ) in zebrafish and mice.lld:pubmed
pubmed-article:20504318pubmed:affiliationCenter for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, ON, K1N 6N5, Canada.lld:pubmed
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