| pubmed-article:20498528 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C0040405 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C0018026 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C0009924 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C2755353 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C1563732 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C1521827 | lld:lifeskim |
| pubmed-article:20498528 | lifeskim:mentions | umls-concept:C1450054 | lld:lifeskim |
| pubmed-article:20498528 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:20498528 | pubmed:dateCreated | 2010-5-25 | lld:pubmed |
| pubmed-article:20498528 | pubmed:abstractText | Gold nanoparticles (Au NPs) are a potential x-ray computed tomography (CT) contrast agent. A biocompatible and bioinactive surface is necessary for application of gold nanoparticle to CT imaging. Polyethylene glycol (PEG)-attached dendrimers have been used as a drug carrier with long blood circulation. In this study, the Au NPs were grown in the PEGylated dendrimer to produce a CT contrast agent. The Au NPs were grown by adding gold ions and ascorbic acid at various equivalents to the Au NP-encapsulated dendrimer solution. Both size and surface plasmon absorption of the grown Au NPs increased with adding a large number of gold ions. The x-ray attenuation of the Au NPs also increased after the seeded growth. The Au NPs grown in the PEG-attached dendrimer at the maximum under our conditions exhibited a similar CT value to a commercial iodine agent, iopamidol, in vitro. The Au NP-loaded PEGylated dendrimer and iopamidol were injected into mice and CT images were obtained at different times. The Au NP-loaded PEGylated dendrimer achieved a blood pool imaging, which was greater than a commercial iodine agent. Even though iopamidol was excreted rapidly, the PEGylated dendrimer loading the grown Au NP was accumulated in the liver. | lld:pubmed |
| pubmed-article:20498528 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20498528 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20498528 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20498528 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20498528 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20498528 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20498528 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20498528 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20498528 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20498528 | pubmed:issn | 1361-6528 | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:KojimaChieC | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:MagataYasuhir... | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:KonoKenjiK | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:HaradaAtsushi... | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:OgawaMikakoM | lld:pubmed |
| pubmed-article:20498528 | pubmed:author | pubmed-author:UmedaYasuhito... | lld:pubmed |
| pubmed-article:20498528 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20498528 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:20498528 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:20498528 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20498528 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20498528 | pubmed:pagination | 245104 | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:meshHeading | pubmed-meshheading:20498528... | lld:pubmed |
| pubmed-article:20498528 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20498528 | pubmed:articleTitle | X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer. | lld:pubmed |
| pubmed-article:20498528 | pubmed:affiliation | Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2 Gakuen-cho, Naka-ku, Sakai, Osaka 599-8570, Japan. c-kojima@21c.osakafu-u.ac.jp | lld:pubmed |
| pubmed-article:20498528 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20498528 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20498528 | pubmed:publicationType | Evaluation Studies | lld:pubmed |
