| pubmed-article:20494340 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C0021759 | lld:lifeskim |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C1711178 | lld:lifeskim |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:20494340 | lifeskim:mentions | umls-concept:C0178987 | lld:lifeskim |
| pubmed-article:20494340 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20494340 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20494340 | pubmed:abstractText | IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD), produced elevated levels of IL-5 mRNA and protein as compared to BEC from naïve mice. To determine the contribution of BEC-derived IL-5 to effector responses in the airways, IL-5 deficient bone marrow chimeric mice were generated in which IL-5 expression was restricted to stromal (e.g. BEC) or hematopoietic cells. When subjected to AAD, IL-5 produced by BECs contributed to mucous metaplasia, airway eosinophilia, and OVA-specific IgA levels. Thus, IL-5 production by BEC can impact the microenvironment of the lung, modifying pathologic and protective immune responses in the airways. | lld:pubmed |
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| pubmed-article:20494340 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20494340 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20494340 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20494340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20494340 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20494340 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20494340 | pubmed:issn | 1090-2163 | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:LiZhuZ | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:PelusoJohn... | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:PuddingtonLyn... | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:WuCarol ACA | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:LingenheldEli... | lld:pubmed |
| pubmed-article:20494340 | pubmed:author | pubmed-author:WalkerSharale... | lld:pubmed |
| pubmed-article:20494340 | pubmed:copyrightInfo | 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20494340 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20494340 | pubmed:volume | 264 | lld:pubmed |
| pubmed-article:20494340 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20494340 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20494340 | pubmed:pagination | 32-41 | lld:pubmed |
| pubmed-article:20494340 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:20494340 | pubmed:meshHeading | pubmed-meshheading:20494340... | lld:pubmed |
| pubmed-article:20494340 | pubmed:meshHeading | pubmed-meshheading:20494340... | lld:pubmed |
