| pubmed-article:20493591 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20493591 | lifeskim:mentions | umls-concept:C0033382 | lld:lifeskim |
| pubmed-article:20493591 | lifeskim:mentions | umls-concept:C0008003 | lld:lifeskim |
| pubmed-article:20493591 | lifeskim:mentions | umls-concept:C1516689 | lld:lifeskim |
| pubmed-article:20493591 | lifeskim:mentions | umls-concept:C0308269 | lld:lifeskim |
| pubmed-article:20493591 | lifeskim:mentions | umls-concept:C1521738 | lld:lifeskim |
| pubmed-article:20493591 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20493591 | pubmed:dateCreated | 2010-6-14 | lld:pubmed |
| pubmed-article:20493591 | pubmed:abstractText | Cocrystallization (formation of a "cocrystal") is an emerging method to optimize physico-chemical properties of pharmaceutically active compounds. One elegant technique used to obtain such cocrystals is grinding the components together, either alone or in the presence of a small amount of solvent (so called solvent-drop grinding). Dry grinding has been used here to obtain cocrystals (actually a hydrated salt) of L-Proline and MnCl(2). In that context, a new crystalline structure of a multicomponent molecular complex composed of L-Proline and MnCl(2) is here reported. The complex was characterized by powder and single-crystal X-ray diffraction and differential scanning calorimetry. This study underlines the interest of grinding as a method to synthesize original solid-state complexes. It also emphasizes the advantage of combining calorimetric and X-ray diffraction to characterize the newly formed solids. Finally, our work provides structural basis for the role that L-Proline can play within multicomponent solid-state molecular complexes, in particular as a potential cocrystal former acting by both ionic and H-bond interactions when combined to molecules of pharmaceutical interest. | lld:pubmed |
| pubmed-article:20493591 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20493591 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20493591 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20493591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20493591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20493591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20493591 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20493591 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20493591 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20493591 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:20493591 | pubmed:author | pubmed-author:WoutersJohanJ | lld:pubmed |
| pubmed-article:20493591 | pubmed:author | pubmed-author:NorbergBernad... | lld:pubmed |
| pubmed-article:20493591 | pubmed:author | pubmed-author:MichauxCather... | lld:pubmed |
| pubmed-article:20493591 | pubmed:author | pubmed-author:TilborgAnaëll... | lld:pubmed |
| pubmed-article:20493591 | pubmed:copyrightInfo | Copyright (c) 2010 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:20493591 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20493591 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:20493591 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20493591 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20493591 | pubmed:pagination | 3511-7 | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:meshHeading | pubmed-meshheading:20493591... | lld:pubmed |
| pubmed-article:20493591 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20493591 | pubmed:articleTitle | Advantages of cocrystallization in the field of solid-state pharmaceutical chemistry: L-Proline and MnCl(2). | lld:pubmed |
| pubmed-article:20493591 | pubmed:affiliation | Department of Chemistry, University of Namur, rue de Bruxelles, 61, B-5000 Namur, Belgium. | lld:pubmed |
| pubmed-article:20493591 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20493591 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
