| pubmed-article:2049062 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2049062 | lifeskim:mentions | umls-concept:C0242692 | lld:lifeskim |
| pubmed-article:2049062 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:2049062 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:2049062 | lifeskim:mentions | umls-concept:C1157202 | lld:lifeskim |
| pubmed-article:2049062 | lifeskim:mentions | umls-concept:C0136151 | lld:lifeskim |
| pubmed-article:2049062 | pubmed:dateCreated | 1991-7-17 | lld:pubmed |
| pubmed-article:2049062 | pubmed:abstractText | 1. The insulin-like effects of orthovanadate (10 mM) and peroxides of vanadate (peroxovanadates, at 1 mM) on rates of lactate formation, glucose oxidation and glycogen synthesis were measured in incubated soleus-muscle preparations isolated from non-obese Wistar rats and lean (fa/?) or insulin-resistant obese Zucker (fa/fa) rats. 2. The stimulation of the rates of lactate formation and glucose oxidation by either orthovanadate or peroxovanadates was of similar magnitude to the stimulation by a maximally effective concentration of insulin (1000 microunits/ml). 3. Peroxovanadates, but not orthovanadate, maximally stimulated the rate of glycogen synthesis in incubated soleus muscles isolated from Wistar rats. 4. When soleus-muscle preparations were incubated in the presence of both insulin (1000 microunits/ml) and peroxovanadates (1 mM), this did not result in a synergistic increase in the rate of total glucose utilization as compared with either agent alone. 5. Soleus muscles isolated from obese (fa/fa) Zucker rats exhibited a decrease in response to a physiologically relevant concentration of insulin (100 microunits/ml). Peroxovanadates, at 1 mM, maximally stimulated the rate of glycogen synthesis in soleus muscles isolated from obese (fa/fa) Zucker rats. 6. The findings indicate that peroxovanadates are useful and important agents for investigating the mechanism of action of insulin in skeletal muscle. | lld:pubmed |
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| pubmed-article:2049062 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2049062 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2049062 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2049062 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2049062 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2049062 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2049062 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:2049062 | pubmed:author | pubmed-author:DiabA MAM | lld:pubmed |
| pubmed-article:2049062 | pubmed:author | pubmed-author:CooperG JGJ | lld:pubmed |
| pubmed-article:2049062 | pubmed:author | pubmed-author:LeightonBB | lld:pubmed |
| pubmed-article:2049062 | pubmed:author | pubmed-author:DaCostaCC | lld:pubmed |
| pubmed-article:2049062 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2049062 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2049062 | pubmed:volume | 276 ( Pt 2) | lld:pubmed |
| pubmed-article:2049062 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2049062 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2049062 | pubmed:pagination | 289-92 | lld:pubmed |
| pubmed-article:2049062 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:2049062 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2049062 | pubmed:articleTitle | Peroxovanadates have full insulin-like effects on glycogen synthesis in normal and insulin-resistant skeletal muscle. | lld:pubmed |
| pubmed-article:2049062 | pubmed:affiliation | Department of Biochemistry, University of Oxford, U.K. | lld:pubmed |
| pubmed-article:2049062 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2049062 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2049062 | lld:pubmed |
