| pubmed-article:20488955 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20488955 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:20488955 | lifeskim:mentions | umls-concept:C0151650 | lld:lifeskim |
| pubmed-article:20488955 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20488955 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20488955 | pubmed:dateCreated | 2010-8-2 | lld:pubmed |
| pubmed-article:20488955 | pubmed:abstractText | TGF-beta/Smad3 promotes renal fibrosis, but the mechanisms that regulate profibrotic genes remain unclear. We hypothesized that miR-192, a microRNA expressed in the kidney may mediate renal fibrosis in a Smad3-dependent manner. Microarray and real-time PCR demonstrated a tight association between upregulation of miR-192 in the fibrotic kidney and activation of TGF-beta/Smad signaling. Deletion of Smad7 promoted miR-192 expression and enhanced Smad signaling and fibrosis in obstructive kidney disease. In contrast, overexpression of Smad7 to block TGF-beta/Smad signaling inhibited miR-192 expression and renal fibrosis in the rat 5/6 nephrectomy model; in vitro, overexpression of Smad7 in tubular epithelial cells abolished TGF-beta1-induced miR-192 expression. Furthermore, Smad3 but not Smad2 mediated TGF-beta1-induced miR-192 expression by binding to the miR-192 promoter. Last, overexpression of a miR-192 mimic promoted and addition of a miR-192 inhibitor blocked TGF-beta1-induced collagen matrix expression. Taken together, miR-192 may be a critical downstream mediator of TGF-beta/Smad3 signaling in the development of renal fibrosis. | lld:pubmed |
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| pubmed-article:20488955 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20488955 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20488955 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20488955 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20488955 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20488955 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20488955 | pubmed:issn | 1533-3450 | lld:pubmed |
| pubmed-article:20488955 | pubmed:author | pubmed-author:LanHui YHY | lld:pubmed |
| pubmed-article:20488955 | pubmed:author | pubmed-author:HuangXiao RXR | lld:pubmed |
| pubmed-article:20488955 | pubmed:author | pubmed-author:ChungArthur... | lld:pubmed |
| pubmed-article:20488955 | pubmed:author | pubmed-author:MengXiaomingX | lld:pubmed |
| pubmed-article:20488955 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20488955 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:20488955 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20488955 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20488955 | pubmed:pagination | 1317-25 | lld:pubmed |
| pubmed-article:20488955 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:meshHeading | pubmed-meshheading:20488955... | lld:pubmed |
| pubmed-article:20488955 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20488955 | pubmed:articleTitle | miR-192 mediates TGF-beta/Smad3-driven renal fibrosis. | lld:pubmed |
| pubmed-article:20488955 | pubmed:affiliation | Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China. | lld:pubmed |
| pubmed-article:20488955 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20488955 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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