| pubmed-article:20484040 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0029418 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C2699153 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0297505 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C0600210 | lld:lifeskim |
| pubmed-article:20484040 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20484040 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20484040 | pubmed:dateCreated | 2010-6-2 | lld:pubmed |
| pubmed-article:20484040 | pubmed:abstractText | Cell adhesion molecules have been implicated in the colonization of cancer cells to distant organs. Prostate cancer (PCa) has a propensity to metastasize to bone, and cadherin-11, which is an osteoblast cadherin aberrantly expressed in PCa cells derived from bone metastases, has been shown to play a role in the metastasis of PCa cells to bone. However, the mechanism by which cadherin-11 is involved in this process is not known. Here, we show that expression of cadherin-11 in cadherin-11-negative C4-2B4 cells increases their spreading and intercalation into an osteoblast layer and also stimulates C4-2B4 cell migration and invasiveness. The downregulation of cadherin-11 in cadherin-11-expressing metastatic PC3 cells decreases cell motility and invasiveness. Further, both the juxtamembrane (JMD) and beta-catenin binding domains (CBS) in the cytoplasmic tail of cadherin-11 are required for cell migration and invasion, but not spreading. Gene array analyses showed that several invasion-related genes, including MMP-7 and MMP-15, are upregulated in cadherin-11-expressing, but not in cad11-DeltaJMD-expressing or cad11-DeltaCBS-expressing, C4-2B4 cells. These observations suggest that cadherin-11 not only provides a physical link between PCa cells and osteoblasts but also increases PCa cell motility and invasiveness that may facilitate the metastatic colonization of PCa cells in bone. | lld:pubmed |
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| pubmed-article:20484040 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20484040 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20484040 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20484040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20484040 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20484040 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20484040 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20484040 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:LogothetisChr... | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:KiddF SFS | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:YeXiangcangX | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:LinSue-HwaSH | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:Yu-LeeLi-Yuan... | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:LeeYu-ChenYC | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:KimSoo MiSM | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:OrtizAngelica... | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:WuFe-Lin... | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:HuangChih-Fen... | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:LiraCristinaC | lld:pubmed |
| pubmed-article:20484040 | pubmed:author | pubmed-author:BilenMehmet... | lld:pubmed |
| pubmed-article:20484040 | pubmed:copyrightInfo | Copyright 2010 AACR. | lld:pubmed |
| pubmed-article:20484040 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20484040 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20484040 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:20484040 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20484040 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20484040 | pubmed:pagination | 4580-9 | lld:pubmed |
| pubmed-article:20484040 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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