| pubmed-article:20481438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C1269955 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0054874 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:20481438 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:20481438 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:20481438 | pubmed:dateCreated | 2010-6-3 | lld:pubmed |
| pubmed-article:20481438 | pubmed:abstractText | A series of small molecules bearing an alpha-ketoamide warhead were synthesized and evaluated for their ability to inhibit cathepsin S, a key proteolytic enzyme upregulated in many cancers during tumor progression and metastasis. Most of the synthetic compounds were noncytotoxic, but several robustly inhibited cathepsin S (IC(50) < 10 nM) and potently suppressed cell migration, invasion, and capillary tube formation. These results highlight the potential of alpha-ketoamide therapy for preventing or delaying cancer spread. | lld:pubmed |
| pubmed-article:20481438 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20481438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20481438 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20481438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20481438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20481438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20481438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20481438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20481438 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20481438 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:UangBiing-Jiu... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:LinChun-Cheng... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:LyuPing-Chian... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChengChao-She... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:HsiehHsing-Pa... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChangJang-Yan... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:KuoChing-Chua... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChangMargaret... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:LiuKo-JiunnKJ | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChangWun-Shai... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChangYi-HsunY... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:WangHsin-Chie... | lld:pubmed |
| pubmed-article:20481438 | pubmed:author | pubmed-author:ChenJo-ChunJC | lld:pubmed |
| pubmed-article:20481438 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20481438 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:20481438 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:20481438 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20481438 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20481438 | pubmed:pagination | 4545-9 | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:meshHeading | pubmed-meshheading:20481438... | lld:pubmed |
| pubmed-article:20481438 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20481438 | pubmed:articleTitle | Design and synthesis of alpha-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis. | lld:pubmed |
| pubmed-article:20481438 | pubmed:affiliation | Department of Chemistry, National Tsing Hua University, 101, Section 2, Kuang-Fu Road, Hsinchu 30013, Taiwan. | lld:pubmed |
| pubmed-article:20481438 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20481438 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20481438 | lld:chembl |
