Linked Life Data

20477793

Source:http://linkedlifedata.com/resource/pubmed/id/20477793

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pubmed-article:20477793pubmed:dateCreated2010-11-18lld:pubmed
pubmed-article:20477793pubmed:abstractTextMutations in the porcine KIT gene (Dominant white locus) have been shown to affect coat colours and colour distribution in pigs. We analysed this gene in several pig breeds and populations (Sicilian black, completely black or with white patches; Cinta Senese; grey local population; Large White; Duroc; Hampshire; Pietrain; wild boar; Meishan) with different coat colours and patterns, genotyping a few polymorphisms. The 21 exons and parts of the intronic regions were sequenced in these pigs and 69 polymorphisms were identified. The grey-roan coat colour observed in a local grey population was completely associated with a 4-bp deletion of intron 18 in a single copy KIT gene, providing evidence that this mutation characterizes the I(d) allele described in the early genetic literature. The white patches observed in black Sicilian pigs were not completely associated with the presence of a duplicated KIT allele (I(p) ), suggesting that genetic heterogeneity is a possible cause of different coat colours in this breed. Selection signature was evident at the KIT gene in two different belted pig breeds, Hampshire and Cinta Senese. The same mutation(s) may cause the belted phenotype in these breeds that originated in the 18th-19th centuries from English pigs (Hampshire) and in Tuscany (Italy) in the 14th century (Cinta Senese). Phylogenetic relationships of 28 inferred KIT haplotypes indicated two clades: one of Asian origin that included Meishan and a few Sicilian black haplotypes and another of European origin.lld:pubmed
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pubmed-article:20477793pubmed:authorpubmed-author:FontanesiLLlld:pubmed
pubmed-article:20477793pubmed:authorpubmed-author:CrovettiAAlld:pubmed
pubmed-article:20477793pubmed:copyrightInfo© 2010 The Authors, Animal Genetics © 2010 Stichting International Foundation for Animal Genetics.lld:pubmed
pubmed-article:20477793pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20477793pubmed:volume41lld:pubmed
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pubmed-article:20477793pubmed:pagination478-92lld:pubmed
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pubmed-article:20477793pubmed:year2010lld:pubmed
pubmed-article:20477793pubmed:articleTitleGenetic heterogeneity and selection signature at the KIT gene in pigs showing different coat colours and patterns.lld:pubmed
pubmed-article:20477793pubmed:affiliationDIPROVAL, Sezione di Allevamenti Zootecnici, Faculty of Agriculture, University of Bologna, Via F.lli Rosselli 107, Reggio Emilia, Italy. luca.fontanesi@unibo.itlld:pubmed
pubmed-article:20477793pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20477793pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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