| pubmed-article:20473866 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0680022 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0002210 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0285761 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C1368105 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C1451005 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C1705325 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C1150481 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20473866 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20473866 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20473866 | pubmed:dateCreated | 2010-11-29 | lld:pubmed |
| pubmed-article:20473866 | pubmed:abstractText | Despite its well-defined role as a serum growth factor during fetal liver development and hepatic oncogenesis, the biological significance of cytoplasmic alpha-fetoprotein (AFP) remains incompletely understood. Here, we provide evidence to illustrate that cytoplasmic AFP may function as a regulator in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway in human hepatocellular carcinoma cells. The results demonstrated colocalization and interaction of AFP and phosphatase and tensin homolog deleted on chromosome 10 (PTEN) in the cytoplasm of AFP-producing Bel 7402 and HepG2 cells, with an interaction distance of 12.6 ± 2.7 Å as determined with the fluorescence resonance energy transfer technique. Knockdown of AFP mRNA or inhibition of AFP expression by all trans-retinoic acid resulted in enhancement of the PTEN level with a synchronous decrease in phosphorylated AKT. Transfection of the afp gene into HLE cells (originally AFP negative) led to a significant activation of AKT signaling. The inhibition of PI3K signaling by LY 294002 was simultaneously reversed by transfection, accompanied by diminution of all trans-retinoic acid-induced upregulation of PTEN and enhancement of cell growth. In conclusion, these results demonstrate that cytoplasmic AFP is involved in regulation of hepatocellular growth and tumorigenesis. | lld:pubmed |
| pubmed-article:20473866 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20473866 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473866 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20473866 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20473866 | pubmed:issn | 1097-0215 | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:FoàVV | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:LiGangG | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:WeiJiangJ | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:LiuXinhuaX | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:WangShanshanS | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:LiuZhongminZ | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:ZhouShengS | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:LiChaoyingC | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:LiMengsenM | lld:pubmed |
| pubmed-article:20473866 | pubmed:author | pubmed-author:McNuttMichael... | lld:pubmed |
| pubmed-article:20473866 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20473866 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20473866 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:20473866 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20473866 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20473866 | pubmed:pagination | 524-32 | lld:pubmed |
| pubmed-article:20473866 | pubmed:meshHeading | pubmed-meshheading:20473866... | lld:pubmed |
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| pubmed-article:20473866 | pubmed:meshHeading | pubmed-meshheading:20473866... | lld:pubmed |
| pubmed-article:20473866 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:20473866 | pubmed:articleTitle | Alpha-fetoprotein: a new member of intracellular signal molecules in regulation of the PI3K/AKT signaling in human hepatoma cell lines. | lld:pubmed |
| pubmed-article:20473866 | pubmed:affiliation | Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, Hainan, China. | lld:pubmed |
| pubmed-article:20473866 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20473866 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
