| pubmed-article:20473297 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C1182711 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0012899 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:20473297 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20473297 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20473297 | pubmed:dateCreated | 2010-6-2 | lld:pubmed |
| pubmed-article:20473297 | pubmed:abstractText | Adult stem cells (SCs) are at high risk of accumulating deleterious mutations because they reside and self-renew in adult tissues for extended periods. Little is known about how adult SCs sense and respond to DNA damage within their natural niche. Here, using mouse epidermis as a model, we define the functional consequences and the molecular mechanisms by which adult SCs respond to DNA damage. We show that multipotent hair-follicle-bulge SCs have two important mechanisms for increasing their resistance to DNA-damage-induced cell death: higher expression of the anti-apoptotic gene Bcl-2 and transient stabilization of p53 after DNA damage in bulge SCs. The attenuated p53 activation is the consequence of a faster DNA repair activity, mediated by a higher non-homologous end joining (NHEJ) activity, induced by the key protein DNA-PK. Because NHEJ is an error-prone mechanism, this novel characteristic of adult SCs may have important implications in cancer development and ageing. | lld:pubmed |
| pubmed-article:20473297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473297 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20473297 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473297 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20473297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20473297 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20473297 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20473297 | pubmed:issn | 1476-4679 | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:MarineJean-Ch... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:SotiropoulouP... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:BlanpainCédri... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:DeneckerGeert... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:DahlEllenE | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:De... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:SemeraroClaud... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:CandiAurélieA | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:YoussefKhalil... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:MascréGuilhem... | lld:pubmed |
| pubmed-article:20473297 | pubmed:author | pubmed-author:LapougeGaelle... | lld:pubmed |
| pubmed-article:20473297 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20473297 | pubmed:volume | 12 | lld:pubmed |
| pubmed-article:20473297 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20473297 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20473297 | pubmed:pagination | 572-82 | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
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| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:meshHeading | pubmed-meshheading:20473297... | lld:pubmed |
| pubmed-article:20473297 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20473297 | pubmed:articleTitle | Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. | lld:pubmed |
| pubmed-article:20473297 | pubmed:affiliation | Interdisciplinary Research Institute (IRIBHM), Université Libre de Bruxelles (ULB), 808, route de Lennik, BatC, C6-130, 1070 Brussels, Belgium. | lld:pubmed |
| pubmed-article:20473297 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20473297 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20473297 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20473297 | lld:pubmed |
