| pubmed-article:20472893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20472893 | lifeskim:mentions | umls-concept:C0029445 | lld:lifeskim |
| pubmed-article:20472893 | lifeskim:mentions | umls-concept:C0012634 | lld:lifeskim |
| pubmed-article:20472893 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20472893 | lifeskim:mentions | umls-concept:C0012544 | lld:lifeskim |
| pubmed-article:20472893 | lifeskim:mentions | umls-concept:C1524003 | lld:lifeskim |
| pubmed-article:20472893 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20472893 | pubmed:dateCreated | 2010-7-7 | lld:pubmed |
| pubmed-article:20472893 | pubmed:abstractText | Bisphosphonate-associated osteonecrosis of the jaw (BONJ) is a morbid bone disease linked to long-term bisphosphonate use. Despite its broad health impact, mechanistic study is lacking. In this study, we have established a mouse model of BONJ-like disease based on the equivalent clinical regimen in myeloma patients, a group associated with high risk of BONJ. We demonstrate that the murine BONJ-like disease recapitulates major clinical and radiographical manifestations of the human disease, including characteristic features of osseous sclerosis, sequestra, avascular, and radiopaque alveolar bone in the jaw that persists beyond a normal course of wound healing following tooth extraction. We find that long-term administration of bisphosphonates results in an increase in the size and number of osteoclasts and the formation of giant osteoclast-like cells within the alveolar bone. We show that the development of necrotic bone and impaired soft tissue healing in our mouse model is dependent on long-term use of high-dose bisphosphonates, immunosuppressive and chemotherapy drugs, as well as mechanical trauma. Most importantly, we demonstrate that bisphosphonate is the major cause of BONJ-like disease in mice, mediated in part by its ability to suppress osseous angiogenesis and bone remodeling. The availability of this novel mouse model of BONJ-like disease will help elucidate the pathophysiology of BONJ and ultimately develop novel approaches for prevention and treatment of human BONJ. | lld:pubmed |
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| pubmed-article:20472893 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20472893 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20472893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20472893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20472893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20472893 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20472893 | pubmed:issn | 1525-2191 | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:ZhangLiL | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:ShiSongtaoS | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:BiYanmingY | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:KikuiriTakash... | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:LeAnhA | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:EhirchiouDris... | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:GaoYameiY | lld:pubmed |
| pubmed-article:20472893 | pubmed:author | pubmed-author:CaoChunzhangC | lld:pubmed |
| pubmed-article:20472893 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20472893 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:20472893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20472893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20472893 | pubmed:pagination | 280-90 | lld:pubmed |
| pubmed-article:20472893 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:20472893 | pubmed:meshHeading | pubmed-meshheading:20472893... | lld:pubmed |
| pubmed-article:20472893 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20472893 | pubmed:articleTitle | Bisphosphonates cause osteonecrosis of the jaw-like disease in mice. | lld:pubmed |
| pubmed-article:20472893 | pubmed:affiliation | University of Maryland School of Medicine, 800 W. Baltimore Street, Baltimore, MD 21201, USA. | lld:pubmed |
| pubmed-article:20472893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20472893 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
