| pubmed-article:20472504 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0032854 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0497169 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1155046 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0231174 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0681842 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1705180 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C1561558 | lld:lifeskim |
| pubmed-article:20472504 | lifeskim:mentions | umls-concept:C0312555 | lld:lifeskim |
| pubmed-article:20472504 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20472504 | pubmed:dateCreated | 2010-8-6 | lld:pubmed |
| pubmed-article:20472504 | pubmed:abstractText | Immune reconstitution after HAART is incomplete, but no widely accepted method to quantify subclinical immune deficiency is available. We immunized 9 HIV-negative subjects and 29 HIV-infected patients with CD4>/=450 cells/microL and undetectable HIV RNA levels with 2 doses of diphtheria/tetanus toxoid (TT) and KLH, a presumed neoantigen. We quantified the response by lymphoproliferative assay, delayed-type hypersensitivity (DTH), and antibody titers up to 59days after enrollment. We assessed T cell proliferative capacity using anti-Vbeta3 and anti-Vbeta5 antibody stimulation, which we herein show induced predominant proliferation of naïve T cells. Subjects with detectable responses to KLH tended to exhibit greater proliferative responses to anti-Vbeta3/Vbeta5 stimulation; no such pattern was seen with response to TT. Several measures of in vitro T cell proliferative capacity correlated significantly with DTH and antibody responses to KLH, but not with TT responses; this association was independent of naïve T cell numbers. Our results indicate that naïve T cell proliferation predicts response to neo-, but not recall antigens, and suggest that it may be a meaningful reflection of in vivo immune competence in HIV-infected persons. | lld:pubmed |
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| pubmed-article:20472504 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20472504 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20472504 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20472504 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20472504 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20472504 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20472504 | pubmed:issn | 1521-7035 | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:LangeChristop... | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:ValdezHernanH | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:MedvikKathyK | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:AsaadRobertR | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:SiegScott FSF | lld:pubmed |
| pubmed-article:20472504 | pubmed:author | pubmed-author:RodriguezBeni... | lld:pubmed |
| pubmed-article:20472504 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20472504 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20472504 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:20472504 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20472504 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20472504 | pubmed:pagination | 400-8 | lld:pubmed |
| pubmed-article:20472504 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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