| pubmed-article:20463067 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20463067 | lifeskim:mentions | umls-concept:C0010825 | lld:lifeskim |
| pubmed-article:20463067 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20463067 | lifeskim:mentions | umls-concept:C0031809 | lld:lifeskim |
| pubmed-article:20463067 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:20463067 | pubmed:issue | 15 | lld:pubmed |
| pubmed-article:20463067 | pubmed:dateCreated | 2010-7-5 | lld:pubmed |
| pubmed-article:20463067 | pubmed:abstractText | Human cytomegalovirus (HCMV) is a human pathogen that causes severe disease primarily in the immunocompromised or immunologically immature individual. To date, no vaccine is available. We describe use of a spread-deficient murine CMV (MCMV) as a novel approach for betaherpesvirus vaccination. To generate a spread-deficient MCMV, the conserved, essential gene M94 was deleted. Immunization with MCMV-DeltaM94 is apathogenic and protective against wild-type challenge even in highly susceptible IFNalphabetaR(-/-) mice. MCMV-DeltaM94 was able to induce a robust CD4(+) and CD8(+) T-cell response as well as a neutralizing antibody response comparable to that induced by wild-type infection. Endothelial cells were identified as activators of CD8(+) T cells in vivo. Thus, the vaccination with a spread-deficient betaherpesvirus is a safe and protective strategy and allows the linkage between cell tropism and immunogenicity. Furthermore, genomes of MCMV-DeltaM94 were present in lungs 12 months after infection, revealing first-target cells as sites of genome maintenance. | lld:pubmed |
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| pubmed-article:20463067 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20463067 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20463067 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20463067 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20463067 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20463067 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20463067 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:20463067 | pubmed:author | pubmed-author:KoszinowskiUl... | lld:pubmed |
| pubmed-article:20463067 | pubmed:author | pubmed-author:RuzsicsZsoltZ | lld:pubmed |
| pubmed-article:20463067 | pubmed:author | pubmed-author:VoehringerDav... | lld:pubmed |
| pubmed-article:20463067 | pubmed:author | pubmed-author:DölkenLarsL | lld:pubmed |
| pubmed-article:20463067 | pubmed:author | pubmed-author:SacherTorsten... | lld:pubmed |
