| pubmed-article:20457474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C1148846 | lld:lifeskim |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C2825490 | lld:lifeskim |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:20457474 | lifeskim:mentions | umls-concept:C0205355 | lld:lifeskim |
| pubmed-article:20457474 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20457474 | pubmed:dateCreated | 2010-6-14 | lld:pubmed |
| pubmed-article:20457474 | pubmed:abstractText | An introduction of the permanent positive charge by methylation of heterocyclic nitrogen on a series of previously studied bis-urea phenanthridine derivatives substantially changed their interactions with DNA and RNA as well as biological activity. At variance to non-methylated analogues, novel methylated derivatives interacted with DNA/RNA not only at pH 5 but also at pH 7, and some compounds switched the DNA binding mode from the minor groove binding (non-methylated derivatives) to the intercalation (novel, methylated derivatives). Moreover, selective ds-RNA over ds-DNA thermal stabilization of previously observed non-methylated derivatives was reversed for novel, methylated derivatives. The variation of a linker length connecting two urea-phenanthridinium conjugates regulated their binding modes toward double stranded polynucleotides. All novel compounds were able to distinguish between polynucleotides of A-T(U) and G-C basepair composition by a specific fluorescence change. Moreover, the introduction of the permanent positive charge on the phenanthridinium moiety resulted in significantly higher biological potency in respect to non-methylated analogues. | lld:pubmed |
| pubmed-article:20457474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20457474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20457474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20457474 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20457474 | pubmed:issn | 1768-3254 | lld:pubmed |
| pubmed-article:20457474 | pubmed:author | pubmed-author:PiantanidaIvo... | lld:pubmed |
| pubmed-article:20457474 | pubmed:author | pubmed-author:Glavas-Obrova... | lld:pubmed |
| pubmed-article:20457474 | pubmed:author | pubmed-author:MarcziSaskaS | lld:pubmed |
| pubmed-article:20457474 | pubmed:author | pubmed-author:Radi... | lld:pubmed |
| pubmed-article:20457474 | pubmed:copyrightInfo | Copyright (c) 2010 Elsevier Masson SAS. All rights reserved. | lld:pubmed |
| pubmed-article:20457474 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20457474 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:20457474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20457474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20457474 | pubmed:pagination | 3281-92 | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:meshHeading | pubmed-meshheading:20457474... | lld:pubmed |
| pubmed-article:20457474 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20457474 | pubmed:articleTitle | Permanent positive charge strongly influences DNA/RNA binding and antiproliferative activity of urea-phenanthridinium conjugates. | lld:pubmed |
| pubmed-article:20457474 | pubmed:affiliation | Laboratory for Study of Interactions of Biomacromolecules, Ruder Boskovi? Institute, P.O.B. 180, HR-10002 Zagreb, Croatia. | lld:pubmed |
| pubmed-article:20457474 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20457474 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20457474 | lld:chembl |
