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pubmed-article:20452292pubmed:abstractTextBrain-derived neurotrophic factor (BDNF) and its cognate receptor, the tyrosine kinase B (TrkB), are normally expressed in neurons and implicated in multiple pathological conditions. Brain-derived neurotrophic factor is produced in the central nervous system microglia in response to noxious stimuli and appear to potentiate central sensitization. Resiniferatoxin (RTX) is an excitotoxic agonist of the vanilloid receptor 1 (VR1), a cation channel protein considered an integrator for nociception. Resiniferatoxin, administered into the dorsal root ganglia (DRG), selectively eliminates the VR1-positive neurons and improves tactile allodynia in a neuropathic pain rat model.lld:pubmed
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pubmed-article:20452292pubmed:articleTitleBrain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment.lld:pubmed
pubmed-article:20452292pubmed:affiliationDepartment of Neurosurgery, Neuroscience Center of Excellence, Health Sciences Center, Louisiana State University, 2020 Gravier Street, New Orleans, LA 70112, USA.lld:pubmed
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