Linked Life Data

20451506

Source:http://linkedlifedata.com/resource/pubmed/id/20451506

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20451506rdf:typepubmed:Citationlld:pubmed
pubmed-article:20451506lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C0022116lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C0205234lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C0598958lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C0243076lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C1999230lld:lifeskim
pubmed-article:20451506lifeskim:mentionsumls-concept:C0205374lld:lifeskim
pubmed-article:20451506pubmed:dateCreated2010-7-8lld:pubmed
pubmed-article:20451506pubmed:abstractTextWe have reported the neuroprotective effects of pre-treatment with beta-adrenoceptor antagonists on the cerebral infarction at 1 and 7 days after focal ischemia in rats. However, the protective effect of post-treatment with beta-adrenoceptor antagonists has not been investigated yet. This study was conducted to evaluate the post-treatment effects of selective beta(1)-adrenoceptor antagonists in the rat focal cerebral ischemia. Halothane anesthetized, normothermic adult male Sprague-Dawley rats were subjected to 2h of middle cerebral artery occlusion (MCAO) using the intraluminal suture technique confirmed by laser Doppler flowmetry. Rats received intravenous infusion of saline 0.5 mL/h, esmolol 200 microg/kg/min, or landiolol 50 microg/kg/min (n=8 in each group). Infusion was initiated 30 min after MCAO and continued for 24h. Rats were allowed to survive for 7 days, and the neurological deficit score was evaluated at 1, 4 and 7 days after reperfusion. The brains were removed and stained with triphenyltetrazolium chloride at 7 days after reperfusion. Neurological deficit scores were lower in the rats treated with esmolol or landiolol, compared with saline-treated rats at 1 day as well as 4 and 7 days. The infarct volumes of cortical and striatum were less in the rats receiving beta-adrenoceptor antagonists than in saline-treated rats (P<0.05). The current study indicates that administration of selective beta1-adrenoceptor antagonists after the onset of ischemia also improved neurological and histological outcomes following transient focal cerebral ischemia in rats.lld:pubmed
pubmed-article:20451506pubmed:languageenglld:pubmed
pubmed-article:20451506pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:citationSubsetIMlld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20451506pubmed:statusMEDLINElld:pubmed
pubmed-article:20451506pubmed:monthJullld:pubmed
pubmed-article:20451506pubmed:issn1872-6240lld:pubmed
pubmed-article:20451506pubmed:authorpubmed-author:HoriguchiTaka...lld:pubmed
pubmed-article:20451506pubmed:authorpubmed-author:GoyagiToruTlld:pubmed
pubmed-article:20451506pubmed:authorpubmed-author:NishikawaTosh...lld:pubmed
pubmed-article:20451506pubmed:authorpubmed-author:TobeYoshitsug...lld:pubmed
pubmed-article:20451506pubmed:copyrightInfoCopyright (c) 2010 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:20451506pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20451506pubmed:day9lld:pubmed
pubmed-article:20451506pubmed:volume1343lld:pubmed
pubmed-article:20451506pubmed:ownerNLMlld:pubmed
pubmed-article:20451506pubmed:authorsCompleteYlld:pubmed
pubmed-article:20451506pubmed:pagination213-7lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:meshHeadingpubmed-meshheading:20451506...lld:pubmed
pubmed-article:20451506pubmed:year2010lld:pubmed
pubmed-article:20451506pubmed:articleTitlePost-treatment with selective ?1 adrenoceptor antagonists provides neuroprotection against transient focal ischemia in rats.lld:pubmed
pubmed-article:20451506pubmed:affiliationDepartment of Anesthesia and Intensive Care Medicine, Akita University Graduate School of Medicine, Akita, Japan. tgoyagi@doc.med.akita-u.ac.jplld:pubmed
pubmed-article:20451506pubmed:publicationTypeJournal Articlelld:pubmed
entrez-gene:24925entrezgene:pubmedpubmed-article:20451506lld:entrezgene