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pubmed-article:2044861pubmed:abstractTextThe development and functional activity of the heart depends on the regulated interaction of cardiac cells. This is in part mediated by cell-cell adhesion molecules such as N-cadherin. N-cadherin belongs to a family of Ca+(+)-dependent, transmembrane, adhesion glycoproteins that promote cell-cell adhesion by molecular self-association extracellularly, and interact intracellularly with the cytoskeleton through highly conserved carboxy-terminal domains. In this paper we show that embryonic chicken cardiac myocytes grown in vitro display Ca+(+)-dependent adhesion and express N-cadherin. When immunoprecipitated from detergent extracts of embryonic chicken cardiac and skeletal muscle cultures, N-cadherin associates with proteins immunologically unrelated to itself. The associated proteins are similar in molecular weight to proteins that coimmunoprecipatate with E-cadherin from human epithelial cells. We postulate that the coimmunoprecipitating proteins are involved in linking the cadherins to the cytoskeleton.lld:pubmed
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pubmed-article:2044861pubmed:authorpubmed-author:KnudsenK AKAlld:pubmed
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pubmed-article:2044861pubmed:articleTitleN-cadherin-associated proteins in chicken muscle.lld:pubmed
pubmed-article:2044861pubmed:affiliationDepartment of Biology, University of Toledo, OH 43606.lld:pubmed
pubmed-article:2044861pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:2044861pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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