| pubmed-article:20442857 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20442857 | lifeskim:mentions | umls-concept:C2350277 | lld:lifeskim |
| pubmed-article:20442857 | lifeskim:mentions | umls-concept:C0914069 | lld:lifeskim |
| pubmed-article:20442857 | lifeskim:mentions | umls-concept:C0577559 | lld:lifeskim |
| pubmed-article:20442857 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:20442857 | lifeskim:mentions | umls-concept:C0489835 | lld:lifeskim |
| pubmed-article:20442857 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20442857 | pubmed:dateCreated | 2010-5-5 | lld:pubmed |
| pubmed-article:20442857 | pubmed:abstractText | Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an emerging risk factor and therapeutic target for cardiovascular disease. The activity and mass of this enzyme are heritable traits, but major genetic determinants have not been explored in a systematic, genome-wide fashion. We carried out a genome-wide association study of Lp-PLA(2) activity and mass in 6,668 Caucasian subjects from the population-based Framingham Heart Study. Clinical data and genotypes from the Affymetrix 550K SNP array were obtained from the open-access Framingham SHARe project. Each polymorphism that passed quality control was tested for associations with Lp-PLA(2) activity and mass using linear mixed models implemented in the R statistical package, accounting for familial correlations, and controlling for age, sex, smoking, lipid-lowering-medication use, and cohort. For Lp-PLA(2) activity, polymorphisms at four independent loci reached genome-wide significance, including the APOE/APOC1 region on chromosome 19 (p = 6 x 10(-24)); CELSR2/PSRC1 on chromosome 1 (p = 3 x 10(-15)); SCARB1 on chromosome 12 (p = 1x10(-8)) and ZNF259/BUD13 in the APOA5/APOA1 gene region on chromosome 11 (p = 4 x 10(-8)). All of these remained significant after accounting for associations with LDL cholesterol, HDL cholesterol, or triglycerides. For Lp-PLA(2) mass, 12 SNPs achieved genome-wide significance, all clustering in a region on chromosome 6p12.3 near the PLA2G7 gene. Our analyses demonstrate that genetic polymorphisms may contribute to inter-individual variation in Lp-PLA(2) activity and mass. | lld:pubmed |
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| pubmed-article:20442857 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20442857 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20442857 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20442857 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20442857 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20442857 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20442857 | pubmed:issn | 1553-7404 | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:GuytonJohn... | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:GinsburgGeoff... | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:McCarthyJeane... | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:SuchindranSun... | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:GaoXiaoyiX | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:RowellJennife... | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:RivedalDavidD | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:MilledgeTomT | lld:pubmed |
| pubmed-article:20442857 | pubmed:author | pubmed-author:BenjaminAshle... | lld:pubmed |
| pubmed-article:20442857 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20442857 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:20442857 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20442857 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20442857 | pubmed:pagination | e1000928 | lld:pubmed |
| pubmed-article:20442857 | pubmed:dateRevised | 2011-3-11 | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:meshHeading | pubmed-meshheading:20442857... | lld:pubmed |
| pubmed-article:20442857 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20442857 | pubmed:articleTitle | Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study. | lld:pubmed |
| pubmed-article:20442857 | pubmed:affiliation | Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, United States of America. | lld:pubmed |
| pubmed-article:20442857 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20442857 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
