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| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C0282641 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C0439750 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C1706942 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20434990 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20434990 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20434990 | pubmed:dateCreated | 2010-5-3 | lld:pubmed |
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| pubmed-article:20434990 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20434990 | pubmed:abstractText | We describe a new repressible binary expression system based on the regulatory genes from the Neurospora qa gene cluster. This "Q system" offers attractive features for transgene expression in Drosophila and mammalian cells: low basal expression in the absence of the transcriptional activator QF, high QF-induced expression, and QF repression by its repressor QS. Additionally, feeding flies quinic acid can relieve QS repression. The Q system offers many applications, including (1) intersectional "logic gates" with the GAL4 system for manipulating transgene expression patterns, (2) GAL4-independent MARCM analysis, and (3) coupled MARCM analysis to independently visualize and genetically manipulate siblings from any cell division. We demonstrate the utility of the Q system in determining cell division patterns of a neuronal lineage and gene function in cell growth and proliferation, and in dissecting neurons responsible for olfactory attraction. The Q system can be expanded to other uses in Drosophila and to any organism conducive to transgenesis. | lld:pubmed |
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| pubmed-article:20434990 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20434990 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20434990 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20434990 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20434990 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20434990 | pubmed:issn | 1097-4172 | lld:pubmed |
| pubmed-article:20434990 | pubmed:author | pubmed-author:XXX | lld:pubmed |
| pubmed-article:20434990 | pubmed:author | pubmed-author:LuoLiqunL | lld:pubmed |
| pubmed-article:20434990 | pubmed:author | pubmed-author:TasicBosiljka... | lld:pubmed |
| pubmed-article:20434990 | pubmed:author | pubmed-author:PotterChristo... | lld:pubmed |
| pubmed-article:20434990 | pubmed:author | pubmed-author:RusslerEmilie... | lld:pubmed |
| pubmed-article:20434990 | pubmed:copyrightInfo | 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20434990 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20434990 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:20434990 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:20434990 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20434990 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20434990 | pubmed:pagination | 536-48 | lld:pubmed |
| pubmed-article:20434990 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:20434990 | pubmed:meshHeading | pubmed-meshheading:20434990... | lld:pubmed |
| pubmed-article:20434990 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20434990 | pubmed:articleTitle | The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis. | lld:pubmed |
| pubmed-article:20434990 | pubmed:affiliation | Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. | lld:pubmed |
| pubmed-article:20434990 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20434990 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20434990 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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