| pubmed-article:20421594 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20421594 | lifeskim:mentions | umls-concept:C1882598 | lld:lifeskim |
| pubmed-article:20421594 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:20421594 | lifeskim:mentions | umls-concept:C1741193 | lld:lifeskim |
| pubmed-article:20421594 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20421594 | pubmed:dateCreated | 2010-7-21 | lld:pubmed |
| pubmed-article:20421594 | pubmed:abstractText | Cerebral ischemia-reperfusion (I/R) insults result in neuronal cell death, brain tissue loss, and severe neurological deficits. However, the underlying mechanism is still not fully understood. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 belongs to a family of RNA-binding proteins that plays a central role in pre-mRNA processing. Recent studies have revealed that hnRNP A2/B1 may be involved in the progress of I/R; therefore, the present study aimed to examine expression patterns of hnRNP A2/B1 to better understand posttranscriptional regulations in cerebral I/R insults. Focal cerebral I/R models were induced by right middle cerebral artery occlusion (MCAO) for 120 min followed by 3, 6, 12, 24, 48, and 72 hr of reperfusion in male Sprague-Dawley rats. We employed immunohistochemistry to examine expression of hnRNP A2/B1 in rat cerebral cortex (including cingulate cortex, striate cortex, temporal cortex, and piriform cortex) and hippocampus after I/R insults. Results showed that expression of hnRNP A2/B1 was significantly downregulated in cerebral cortex and hippocampus from 3 to 24 hr of reperfusion after MCAO for 120 min, but significantly upregulated at 48 hr of reperfusion. Unexpectedly, translocation of hnRNP A2/B1 from nucleus to cytoplasm and even to neurites was observed in cerebral cortex at 3 hr of reperfusion, reaching a peak at 24 hr of reperfusion, but not in hippocampus, indicating different posttranscriptional regulation patterns in different brain regions. Interestingly, translocation of hnRNP A2/B1 was only observed in cerebral cortex with MCAO but not in the opposite side, suggesting an I/R-specific expression pattern in the brain. Our data suggest that hnRNP A2/B1 participates in posttranscriptional regulation of neurons in cerebral cortex and hippocampus that suffered I/R insults, although posttranscriptional regulation is more extensive in neuronal cells of cerebral cortex than in hippocampus. | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20421594 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20421594 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20421594 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20421594 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20421594 | pubmed:issn | 1551-5044 | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:YenI HIH | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:RíoLL | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:ZhangChenggan... | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:WangHangyanH | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:WuYonghongY | lld:pubmed |
| pubmed-article:20421594 | pubmed:author | pubmed-author:LiuYichenY | lld:pubmed |
| pubmed-article:20421594 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20421594 | pubmed:volume | 58 | lld:pubmed |
| pubmed-article:20421594 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20421594 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20421594 | pubmed:pagination | 695-705 | lld:pubmed |
| pubmed-article:20421594 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
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| pubmed-article:20421594 | pubmed:meshHeading | pubmed-meshheading:20421594... | lld:pubmed |
| pubmed-article:20421594 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20421594 | pubmed:articleTitle | Histochemical mapping of hnRNP A2/B1 in rat brain after ischemia-reperfusion insults. | lld:pubmed |
| pubmed-article:20421594 | pubmed:affiliation | Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Beijing, China. | lld:pubmed |
| pubmed-article:20421594 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20421594 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:362361 | entrezgene:pubmed | pubmed-article:20421594 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20421594 | lld:entrezgene |
