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pubmed-article:20418085pubmed:abstractTextChronic eosinophilic inflammation may promote bronchial hyperresponsiveness (BHR), which involves reversible reduction of airflow and airway remodelling such as a thickening of the reticular basement membrane (RBM) and hypertrophy and hyperplasia of airway smooth muscle (ASM). BHR to histamine (Hist) and acetylcholine (ACh) cannot differentiate airway inflammation and remodelling.lld:pubmed
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pubmed-article:20418085pubmed:articleTitleBronchial hyperresponsiveness to histamine correlates with airway remodelling in adults with asthma.lld:pubmed
pubmed-article:20418085pubmed:affiliationNational Hospital Organization Sagamihara National Hospital, Sakuradai Sagamihara, Kanagawa, Japan. n-tsurikisawa@sagamihara-hosp.gr.jplld:pubmed
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