| pubmed-article:20413589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20413589 | lifeskim:mentions | umls-concept:C0812258 | lld:lifeskim |
| pubmed-article:20413589 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:20413589 | lifeskim:mentions | umls-concept:C0012860 | lld:lifeskim |
| pubmed-article:20413589 | lifeskim:mentions | umls-concept:C0524550 | lld:lifeskim |
| pubmed-article:20413589 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:20413589 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:20413589 | pubmed:dateCreated | 2010-6-15 | lld:pubmed |
| pubmed-article:20413589 | pubmed:abstractText | The E2F1 transcription factor is a well known regulator of cell proliferation and apoptosis, but its role in the DNA damage response is less clear. Using a local UV irradiation technique and immunofluorescence staining, E2F1 is shown to accumulate at sites of DNA damage. Localization of E2F1 to UV-damaged DNA requires the ATM and Rad3-related (ATR) kinase and serine 31 of E2F1 but not an intact DNA binding domain. E2F1 deficiency does not appear to affect the expression of nucleotide excision repair (NER) factors, such as XPC and XPA. However, E2F1 depletion does impair the recruitment of NER factors to sites of damage and reduces the efficiency of DNA repair. E2F1 mutants unable to bind DNA or activate transcription retain the ability to stimulate NER. These findings demonstrate that E2F1 has a direct, non-transcriptional role in DNA repair involving increased recruitment of NER factors to sites of damage. | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20413589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20413589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20413589 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20413589 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:ChenJieJ | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:JohnsonDavid... | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:ZhuFengF | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:MitchellDavid... | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:BertonThomas... | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:GuoRuifengR | lld:pubmed |
| pubmed-article:20413589 | pubmed:author | pubmed-author:BiswasAnup... | lld:pubmed |
| pubmed-article:20413589 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20413589 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:20413589 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:20413589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20413589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20413589 | pubmed:pagination | 19308-15 | lld:pubmed |
| pubmed-article:20413589 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
| pubmed-article:20413589 | pubmed:meshHeading | pubmed-meshheading:20413589... | lld:pubmed |
