Experimental evidence suggests that the healing of diabetic foot ulcers is affected by psychosocial factors such as distress. We examined this proposal in a prospective study, in which we considered the role of psychological distress and coping style in the healing of diabetic foot ulcers over a 24 week period. We also explored the role of salivary cortisol and matrix metalloproteinases (MMPs) as potential mechanisms.
Institute of Work, Health and Organisations, International House, University of Nottingham, Jubilee Campus, Nottingham NG8 1BB, UK. Kavita.Vedhara@nottingham.ac.uk