Linked Life Data

20405575

Source:http://linkedlifedata.com/resource/pubmed/id/20405575

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pubmed-article:20405575pubmed:abstractTextThe inflammatory response after prolonged ischemia and subsequent reperfusion leads to increased risk of primary organ dysfunction after cardiac transplantation. It has been demonstrated that the fibrin-derived peptide Bbeta(15-42) (also called FX06) reduces infarct size in coronary artery occlusion/reperfusion models by inhibition of leukocyte migration. Further, Bbeta(15-42) preserves endothelial barrier function. The purpose of this study was to investigate whether Bbeta(15-42) has a protective effect in cardiac allografts exposed to prolonged global ischemia and subsequent in vivo reperfusion.lld:pubmed
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pubmed-article:20405575pubmed:articleTitleThe fibrin-derived peptide Bbeta(15-42) significantly attenuates ischemia-reperfusion injury in a cardiac transplant model.lld:pubmed
pubmed-article:20405575pubmed:affiliationDepartment of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria.lld:pubmed
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