| pubmed-article:20400676 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20400676 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:20400676 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:20400676 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:20400676 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:20400676 | lifeskim:mentions | umls-concept:C0332185 | lld:lifeskim |
| pubmed-article:20400676 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20400676 | pubmed:dateCreated | 2010-7-1 | lld:pubmed |
| pubmed-article:20400676 | pubmed:abstractText | This study aimed to identify the inflammation-associated 7/4-antigen, which is highly expressed on neutrophils, inflammatory monocytes, some activated macrophages, as well as on bone marrow myeloid-restricted progenitors. The high expression on inflammatory cells is suggestive of a role in inflammation and makes the 7/4-antigen a potential target for the manipulation of inflammatory cells. Consistent with this, the 7/4-antibody mediates specific depletion of 7/4-expressing neutrophils and monocytes. We have identified the 7/4-antigen as a 25- to 30-kDa GPI-anchored glycoprotein synonymous with the Ly-6B.2 alloantigen. We characterized the expression of Ly-6B during the inflammatory reaction induced by zymosan. During the later stages of an experimental, acute, self-resolving inflammatory response, we found that Ly-6B is differentially expressed on macrophages. Ly-6B-expressing macrophages also express more MHCII, CIITA, CCR2, Ly-6C, and CD62L than the Ly-6B-negative macrophages, which in turn, express more of the resident tissue macrophage marker SIGN-R1 and higher CD11b and F4/80. Ly-6B-expressing macrophages incorporate more BrdU than their Ly-6B-negative contemporaries when fed during the resolution phase of the acute inflammatory response. Thus, Ly-6B expression on mature macrophages defines a subset of recently generated inflammatory macrophages that retain monocytic markers and is hence a surrogate marker of macrophage turnover in inflammatory lesions. The definition of the 7/4:Ly-6B antigen will allow further characterization and specific modulation of Ly-6B-expressing cells in vivo. | lld:pubmed |
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| pubmed-article:20400676 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20400676 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20400676 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20400676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20400676 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20400676 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20400676 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20400676 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:20400676 | pubmed:author | pubmed-author:GordonSiamonS | lld:pubmed |
| pubmed-article:20400676 | pubmed:author | pubmed-author:StaceyMartinM | lld:pubmed |
| pubmed-article:20400676 | pubmed:author | pubmed-author:TaylorPhilip... | lld:pubmed |
| pubmed-article:20400676 | pubmed:author | pubmed-author:ThomasBenjami... | lld:pubmed |
| pubmed-article:20400676 | pubmed:author | pubmed-author:RosasMarcelaM | lld:pubmed |
| pubmed-article:20400676 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20400676 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:20400676 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20400676 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20400676 | pubmed:pagination | 169-80 | lld:pubmed |
| pubmed-article:20400676 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:20400676 | pubmed:meshHeading | pubmed-meshheading:20400676... | lld:pubmed |
| pubmed-article:20400676 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20400676 | pubmed:articleTitle | The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B. | lld:pubmed |
| pubmed-article:20400676 | pubmed:affiliation | Infection, Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, UK. | lld:pubmed |
| pubmed-article:20400676 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20400676 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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