| pubmed-article:20383327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C0003402 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C0016719 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20383327 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20383327 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20383327 | pubmed:dateCreated | 2010-4-12 | lld:pubmed |
| pubmed-article:20383327 | pubmed:abstractText | Cells from individuals with Friedreich's ataxia (FRDA) show reduced activities of antioxidant enzymes and cannot up-regulate their expression when exposed to oxidative stress. This blunted antioxidant response may play a central role in the pathogenesis. We previously reported that Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Coactivator 1-alpha (PGC-1alpha), a transcriptional master regulator of mitochondrial biogenesis and antioxidant responses, is down-regulated in most cell types from FRDA patients and animal models. | lld:pubmed |
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| pubmed-article:20383327 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20383327 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20383327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20383327 | pubmed:issn | 1932-6203 | lld:pubmed |
| pubmed-article:20383327 | pubmed:author | pubmed-author:PandolfoMassi... | lld:pubmed |
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| pubmed-article:20383327 | pubmed:author | pubmed-author:MantoMarioM | lld:pubmed |
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| pubmed-article:20383327 | pubmed:author | pubmed-author:VergaraPaolaP | lld:pubmed |
| pubmed-article:20383327 | pubmed:author | pubmed-author:MarmolinoDani... | lld:pubmed |
| pubmed-article:20383327 | pubmed:author | pubmed-author:RavellaAjayA | lld:pubmed |
| pubmed-article:20383327 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20383327 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:20383327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20383327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20383327 | pubmed:pagination | e10025 | lld:pubmed |
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| pubmed-article:20383327 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20383327 | pubmed:articleTitle | PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. | lld:pubmed |
| pubmed-article:20383327 | pubmed:affiliation | Laboratoire de Neurologie Expérimentale, Université Libre de Bruxelles, Brussels, Belgium. | lld:pubmed |
| pubmed-article:20383327 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20383327 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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