Linked Life Data

20381450

Source:http://linkedlifedata.com/resource/pubmed/id/20381450

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20381450rdf:typepubmed:Citationlld:pubmed
pubmed-article:20381450lifeskim:mentionsumls-concept:C0018787lld:lifeskim
pubmed-article:20381450lifeskim:mentionsumls-concept:C0010536lld:lifeskim
pubmed-article:20381450lifeskim:mentionsumls-concept:C1545588lld:lifeskim
pubmed-article:20381450lifeskim:mentionsumls-concept:C1096176lld:lifeskim
pubmed-article:20381450lifeskim:mentionsumls-concept:C1159825lld:lifeskim
pubmed-article:20381450lifeskim:mentionsumls-concept:C0127400lld:lifeskim
pubmed-article:20381450pubmed:issue6-7lld:pubmed
pubmed-article:20381450pubmed:dateCreated2010-6-21lld:pubmed
pubmed-article:20381450pubmed:abstractTextWe have previously reported that estradiol can protect heart mitochondria from the ischemia-induced mitochondrial permeability transition pore-related release of cytochrome c and subsequent apoptosis. In this study we investigated whether the effect of 17-beta-estradiol on ischemia-induced mitochondrial dysfunctions and apoptosis is mediated by activation of signaling protein kinases in a Langendorff-perfused rat heart model of stop-flow ischemia. We found that pre-perfusion of non-ischemic hearts with 100nM estradiol increased the resistance of subsequently isolated mitochondria to the calcium-induced opening of mitochondrial permeability transition pore and this was mediated by protein kinase G. Loading of the hearts with estradiol prevented ischemia-induced loss of cytochrome c from mitochondria and respiratory inhibition and these effects were reversed in the presence of the inhibitor of Akt kinase, NO synthase inhibitor L-NAME, guanylyl cyclase inhibitor ODQ and protein kinase G inhibitor KT5823. Estradiol prevented ischemia-induced activation of caspases and this was also reversed by KT5823. These findings suggest that estradiol may protect the heart against ischemia-induced injury activating the signaling cascade which involves Akt kinase, NO synthase, guanylyl cyclase and protein kinase G, and results in blockage of mitochondrial permeability transition pore-induced release of cytochrome c from mitochondria, respiratory inhibition and activation of caspases.lld:pubmed
pubmed-article:20381450pubmed:languageenglld:pubmed
pubmed-article:20381450pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:citationSubsetIMlld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20381450pubmed:statusMEDLINElld:pubmed
pubmed-article:20381450pubmed:issn0006-3002lld:pubmed
pubmed-article:20381450pubmed:authorpubmed-author:MorkunieneRam...lld:pubmed
pubmed-article:20381450pubmed:authorpubmed-author:BorutaiteVilm...lld:pubmed
pubmed-article:20381450pubmed:authorpubmed-author:IvanovieneLai...lld:pubmed
pubmed-article:20381450pubmed:authorpubmed-author:Arandarcikait...lld:pubmed
pubmed-article:20381450pubmed:copyrightInfoCopyright © 2010 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:20381450pubmed:issnTypePrintlld:pubmed
pubmed-article:20381450pubmed:volume1797lld:pubmed
pubmed-article:20381450pubmed:ownerNLMlld:pubmed
pubmed-article:20381450pubmed:authorsCompleteYlld:pubmed
pubmed-article:20381450pubmed:pagination1012-7lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:meshHeadingpubmed-meshheading:20381450...lld:pubmed
pubmed-article:20381450pubmed:articleTitleEstradiol-induced protection against ischemia-induced heart mitochondrial damage and caspase activation is mediated by protein kinase G.lld:pubmed
pubmed-article:20381450pubmed:affiliationInstitute for Biomedical Research, Department of Biochemistry, Kaunas University of Medicine, Eiveniu 4, LT-50009 Kaunas, Lithuania.lld:pubmed
pubmed-article:20381450pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20381450pubmed:publicationTypeIn Vitrolld:pubmed