| pubmed-article:20373009 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20373009 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20373009 | lifeskim:mentions | umls-concept:C0079731 | lld:lifeskim |
| pubmed-article:20373009 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:20373009 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:20373009 | lifeskim:mentions | umls-concept:C0033522 | lld:lifeskim |
| pubmed-article:20373009 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20373009 | pubmed:dateCreated | 2010-7-14 | lld:pubmed |
| pubmed-article:20373009 | pubmed:abstractText | Cytokines play important roles in B-cell activation, proliferation, and apoptosis, thus may be etiologically related to risk of B-cell non-Hodgkin lymphoma (B-NHL). However, the association between circulating levels of cytokines and B-NHL risk has not been prospectively studied in non-HIV populations. The objective of this study was to assess this association by conducting a case-control study nested within a prospective cohort of non-HIV-infected, healthy women. Fifteen cytokines were measured in samples collected a median of 8.2 years prior to diagnosis in 92 cases and two matched controls per case. Only cytokines that showed adequate temporal reproducibility over a two-year period were included. The odds ratio (OR) for the highest tertile relative to the lowest was elevated for soluble IL-2 receptor (sIL-2R) (OR = 2.5, 95% CI = 1.4-4.7, p (trend) < 0.01) and decreased for IL-13 (OR = 0.5, 95% CI = 0.2-1.0, p (trend) = 0.05). Three other cytokines were marginally associated with risk of B-NHL: TNF-alpha (OR = 1.7, 95% CI = 0.9-3.3, p (trend) = 0.11), sTNF-R2 (OR = 1.9, 95% CI = 0.9-3.5, p (trend) = 0.06), and IL-5 (OR = 0.5, 95% CI = 0.3-1.0, p (trend) = 0.06). No association was observed between B-NHL risk and levels of the other cytokines measured (IL-1beta, IL-1RA, IL-2, IL-4, IL-6, IL-10, IL-12, IL-12p70, CRP and sTNF-R1). This study suggests that dysregulated cytokines may be involved in B-NHL development. | lld:pubmed |
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| pubmed-article:20373009 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20373009 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20373009 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20373009 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20373009 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20373009 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20373009 | pubmed:issn | 1573-7225 | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:ShoreRoy ERE | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:Zeleniuch-Jac... | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:KoenigKaren... | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:IbrahimSherif... | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:LokshinAnna... | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:ArslanAlan... | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:GuYianY | lld:pubmed |
| pubmed-article:20373009 | pubmed:author | pubmed-author:LiuMenglingM | lld:pubmed |
| pubmed-article:20373009 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20373009 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:20373009 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20373009 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20373009 | pubmed:pagination | 1323-33 | lld:pubmed |
| pubmed-article:20373009 | pubmed:dateRevised | 2011-8-3 | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:meshHeading | pubmed-meshheading:20373009... | lld:pubmed |
| pubmed-article:20373009 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20373009 | pubmed:articleTitle | Circulating cytokines and risk of B-cell non-Hodgkin lymphoma: a prospective study. | lld:pubmed |
| pubmed-article:20373009 | pubmed:affiliation | Department of Environmental Medicine, New York University School of Medicine, 650 First Avenue, New York, NY 10016-3240, USA. | lld:pubmed |
| pubmed-article:20373009 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20373009 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
