| pubmed-article:20372150 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C0005612 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C1437703 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C1427008 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C1412224 | lld:lifeskim |
| pubmed-article:20372150 | lifeskim:mentions | umls-concept:C0743925 | lld:lifeskim |
| pubmed-article:20372150 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20372150 | pubmed:dateCreated | 2010-4-29 | lld:pubmed |
| pubmed-article:20372150 | pubmed:abstractText | To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (n = 10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in 13 replication studies (n = 27,591). rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight. Correlated SNPs in ADCY5 were recently implicated in regulation of glucose levels and susceptibility to type 2 diabetes, providing evidence that the well-described association between lower birth weight and subsequent type 2 diabetes has a genetic component, distinct from the proposed role of programming by maternal nutrition. Using data from both SNPs, we found that the 9% of Europeans carrying four birth weight-lowering alleles were, on average, 113 g (95% CI 89-137 g) lighter at birth than the 24% with zero or one alleles (P(trend) = 7 x 10(-30)). The impact on birth weight is similar to that of a mother smoking 4-5 cigarettes per day in the third trimester of pregnancy. | lld:pubmed |
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| pubmed-article:20372150 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20372150 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20372150 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20372150 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20372150 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20372150 | pubmed:month | May | lld:pubmed |
| pubmed-article:20372150 | pubmed:issn | 1546-1718 | lld:pubmed |
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